Alternative titles; symbols
HGNC Approved Gene Symbol: DUSP7
Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,048,919-52,056,571 (from NCBI)
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see 601795), JNK (see 601158), and p38 (see 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009).
Muda et al. (1996) identified rat superior cervical ganglion cDNAs encoding 2 dual-specificity phosphatases that they designated MKP3 (DUSP6; 602748) and MKPX. The predicted 280-amino acid sequence of the partial MKPX cDNA was 76% identical to that of MKP3.
Groom et al. (1996) identified cDNAs encoding the human MKP3 and MKPX homologs, which they called PYST1 and PYST2, respectively. The predicted amino acid sequence of the partial PYST2 cDNA was 73% identical to that of PYST1. Northern blot analysis revealed that the 3.5-kb PYST2 mRNA was expressed at low levels in several tissues. In liver, Groom et al. (1996) observed strong expression of a 2.5-kb transcript and much weaker expression of a 5-kb transcript.
By analysis of somatic cell hybrids and fluorescence in situ hybridization, Smith et al. (1997) mapped the DUSP7 gene to 3p21. They localized the mouse Dusp7 gene to chromosome 9.
Groom, L. A., Sneddon, A. A., Alessi, D. R., Dowd, S., Keyse, S. M. Differential regulation of the MAP, SAP and Rk/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15: 3621-3632, 1996. [PubMed: 8670865]
Muda, M., Boschert, U., Dickinson, R., Martinou, J.-C., Martinou, I., Camps, M., Schlegel, W., Arkinstall, S. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J. Biol. Chem. 271: 4319-4326, 1996. [PubMed: 8626780] [Full Text: https://doi.org/10.1074/jbc.271.8.4319]
Patterson, K. I., Brummer, T., O'Brien, P. M., Daly, R. J. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem. J. 418: 475-489, 2009. [PubMed: 19228121] [Full Text: https://doi.org/10.1042/bj20082234]
Smith, A., Price, C., Cullen, M., Muda, M., King, A., Ozanne, B., Arkinstall, S., Ahsworth, A. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). Genomics 42: 524-527, 1997. [PubMed: 9205128] [Full Text: https://doi.org/10.1006/geno.1997.4756]