Alternative titles; symbols
HGNC Approved Gene Symbol: H2AC8
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,216,921-26,217,437 (from NCBI)
For background information on histones, histone gene clusters, and the H2A histone family, see HIST1H2AA (613499).
Albig et al. (1991) identified a gene encoding a member of the H2A class of histones and designated it H2A.1. Albig and Doenecke (1997) designated this gene H2A/a.
By analysis of a YAC contig, Albig et al. (1997) mapped the H2A/a gene to chromosome 6p21.3, within a cluster of 35 histone genes.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H2AE.
See HIST1H2AA (613499) for functional information on H2A histones.
Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]
Albig, W., Kardalinou, E., Drabent, B., Zimmer, A., Doenecke, D. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Genomics 10: 940-948, 1991. [PubMed: 1916825] [Full Text: https://doi.org/10.1016/0888-7543(91)90183-f]
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]