Alternative titles; symbols
HGNC Approved Gene Symbol: H2AC20
Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,886,918-149,887,411 (from NCBI)
For background information on histones, histone gene clusters, and the H2A histone family, see HIST1H2AA (613499).
Collart et al. (1992) cloned a histone H2B gene (601831), which they termed H2B.1, from a human genomic DNA library. They found that this H2B gene is paired with a functional H2A histone gene. Albig and Doenecke (1997) designated this H2A gene H2A/q.
Collart et al. (1992) found that the H2B.1 and H2A/q genes are separated by a bidirectionally transcribed intergenic promoter region of 329 nucleotides containing consensus TATA and CCAAT boxes and an OTF1 (POU2F1; 164175) element.
Collart et al. (1992) mapped the H2B.1 gene, which is paired with the H2A/q gene, to human chromosome 1q21-q23 using a somatic cell hybrid panel and in situ hybridization.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 1q21, which they called histone gene cluster-2 (HIST2), contains 6 histone genes, including HIST2H2AC.
See HIST1H2AA (613499) for functional information on H2A histones.
Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]
Collart, D., Romain, P. L., Huebner, K., Pockwinse, S., Pilapil, S., Cannizzaro, L. A., Lian, J. B., Croce, C. M., Stein, J. L., Stein, G. S. A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3-prime end processing. J. Cell. Biochem. 50: 374-385, 1992. [PubMed: 1469070] [Full Text: https://doi.org/10.1002/jcb.240500406]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]