Alternative titles; symbols
HGNC Approved Gene Symbol: H3C6
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,224,178-26,227,473 (from NCBI)
For background information on histones, histone gene clusters, and the H3 histone family, see HIST1H3A (602810).
Albig et al. (1991) identified a gene encoding a member of the H3 class of histones and designated it H3.1. Albig and Doenecke (1997) designated this gene H3/d.
By genomic sequence analysis, Marzluff et al. (2002) identified the mouse and human HIST1H3E genes. They noted that all H3 genes in histone gene cluster-1 (HIST1), including HIST1H3E, encode the same protein, designated H3.1. H3.1 differs from H3.2, which is encoded by HIST2H3C (142780), at only 1 residue, and from histone H3.3, which is encoded by both H3F3A (601128) and H3F3B (601058), at a few residues.
By analysis of a YAC contig, Albig et al. (1997) mapped the H3/d gene to chromosome 6p21.3, within a cluster of 35 histone genes.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called HIST1, contains 55 histone genes, including HIST1H3E.
See HIST1H3A (602810) for functional information on H3.1 and the H3 histone family.
Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]
Albig, W., Kardalinou, E., Drabent, B., Zimmer, A., Doenecke, D. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Genomics 10: 940-948, 1991. [PubMed: 1916825] [Full Text: https://doi.org/10.1016/0888-7543(91)90183-f]
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966]