Alternative titles; symbols
HGNC Approved Gene Symbol: H3C8
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,270,918-26,271,413 (from NCBI)
For background information on histones, histone gene clusters, and the H3 histone family, see HIST1H3A (602810).
By genomic sequence analysis, Marzluff et al. (2002) identified the mouse and human HIST1H3G genes. They noted that all H3 genes in histone gene cluster-1 (HIST1), including HIST1H3G, encode the same protein, designated H3.1. H3.1 differs from H3.2, which is encoded by HIST2H3C (142780), at only 1 residue, and from histone H3.3, which is encoded by both H3F3A (601128) and H3F3B (601058), at a few residues.
By analysis of a YAC contig from chromosome 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes that included H3/h.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called HIST1, contains 55 histone genes, including HIST1H3G.
See HIST1H3A (602810) for functional information on H3.1 and the H3 histone family.
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]