Entry - *602817 - HISTONE GENE CLUSTER 1, H3 HISTONE FAMILY, MEMBER J; HIST1H3J - OMIM

 
 
* 602817

HISTONE GENE CLUSTER 1, H3 HISTONE FAMILY, MEMBER J; HIST1H3J


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H3J
HIST1 CLUSTER, H3J
H3 HISTONE FAMILY, MEMBER J; H3FJ
H3/J


HGNC Approved Gene Symbol: H3C12

Cytogenetic location: 6p22.1     Genomic coordinates (GRCh38): 6:27,890,315-27,890,826 (from NCBI)


▼ TEXT

For background information on histones, histone gene clusters, and the H3 histone family, see HIST1H3A (602810).

▼ Cloning and Expression

By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H3J gene. They noted that all H3 genes in histone gene cluster-1 (HIST1), including HIST1H3J, encode the same protein, designated H3.1. H3.1 differs from H3.2, which is encoded by HIST2H3C (142780), at only 1 residue, and from histone H3.3, which is encoded by both H3F3A (601128) and H3F3B (601058), at a few residues.


▼ Mapping

By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H3/j, located 2 Mb centromeric to the major histone gene cluster.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called HIST1, contains 55 histone genes, including HIST1H3J.


▼ Gene Function

See HIST1H3A (602810) for functional information on H3.1 and the H3 histone family.

▼ REFERENCES

  1. Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656, related citations] [Full Text]

  2. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966, related citations]


Contributors:
Matthew B. Gross - updated : 02/04/2013
Creation Date:
Rebekah S. Rasooly : 7/9/1998
Edit History:
mgross : 02/04/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998

* 602817

HISTONE GENE CLUSTER 1, H3 HISTONE FAMILY, MEMBER J; HIST1H3J


Alternative titles; symbols

HISTONE GENE CLUSTER 1, H3J
HIST1 CLUSTER, H3J
H3 HISTONE FAMILY, MEMBER J; H3FJ
H3/J


HGNC Approved Gene Symbol: H3C12

Cytogenetic location: 6p22.1     Genomic coordinates (GRCh38): 6:27,890,315-27,890,826 (from NCBI)


TEXT

For background information on histones, histone gene clusters, and the H3 histone family, see HIST1H3A (602810).

Cloning and Expression

By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H3J gene. They noted that all H3 genes in histone gene cluster-1 (HIST1), including HIST1H3J, encode the same protein, designated H3.1. H3.1 differs from H3.2, which is encoded by HIST2H3C (142780), at only 1 residue, and from histone H3.3, which is encoded by both H3F3A (601128) and H3F3B (601058), at a few residues.


Mapping

By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H3/j, located 2 Mb centromeric to the major histone gene cluster.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called HIST1, contains 55 histone genes, including HIST1H3J.


Gene Function

See HIST1H3A (602810) for functional information on H3.1 and the H3 histone family.

REFERENCES

  1. Albig, W., Doenecke, D. The human histone gene cluster at the D6S105 locus. Hum. Genet. 101: 284-294, 1997. [PubMed: 9439656] [Full Text: https://doi.org/10.1007/s004390050630]

  2. Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966]


Contributors:
Matthew B. Gross - updated : 02/04/2013

Creation Date:
Rebekah S. Rasooly : 7/9/1998

Edit History:
mgross : 02/04/2013
mgross : 7/22/2010
tkritzer : 3/31/2003
alopez : 8/26/1998
alopez : 7/14/1998
alopez : 7/10/1998



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 28, 2024