Alternative titles; symbols
HGNC Approved Gene Symbol: H4C8
Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,285,126-26,285,534 (from NCBI)
For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).
By genomic sequence analysis, Marzluff et al. (2002) identified the mouse and human HIST1H4H genes. All mouse and human H4 genes, including HIST1H4H, encode the same protein.
By analysis of a YAC contig from chromosome 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes, including H4/h.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4H.
See HIST1H4A (602822) for functional information on H4 histones.
Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. [PubMed: 9119399] [Full Text: https://doi.org/10.1006/geno.1996.4592]
Marzluff, W. F., Gongidi, P., Woods, K. R., Jin, J., Maltais, L. J. The human and mouse replication-dependent histone genes. Genomics 80: 487-498, 2002. [PubMed: 12408966] [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0888754302968503]