HGNC Approved Gene Symbol: KIF3C
Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:25,926,598-25,982,497 (from NCBI)
By screening a human fetal brain cDNA library with probes based on a sequence in the expressed sequence tag (EST) database, Telford et al. (1998) cloned a novel kinesin-related gene. The full-length cDNA sequence predicted a 793-amino acid polypeptide that was 98% identical to that of the mouse Kif3c gene. Northern blot analysis revealed that KIF3C expressed a 5.0-kb mRNA in brain and 3 smaller mRNAs in all tested tissues.
By PCR and DNA sequence analysis of PAC clones, Telford et al. (1998) found that the human KIF3C gene consists of 8 exons spanning 12 kb.
Telford et al. (1998) used fluorescence in situ hybridization to map the KIF3C gene to human chromosome 2p23. They used interspecific backcross analysis to map the gene to mouse chromosome 12.
Lawrence et al. (2004) presented a standardized kinesin nomenclature based on 14 family designations. Under this system, KIF3C belongs to the kinesin-2 family.
Lawrence, C. J., Dawe, R. K., Christie, K. R., Cleveland, D. W., Dawson, S. C., Endow, S. A., Goldstein, L. S. B., Goodson, H. V., Hirokawa, N., Howard, J., Malmberg, R. L., McIntosh, J. R., and 10 others. A standardized kinesin nomenclature. J. Cell Biol. 167: 19-22, 2004. [PubMed: 15479732] [Full Text: https://doi.org/10.1083/jcb.200408113]
Telford, E. A. R., Wightman, P., Leek, J., Markham, A. F., Lench, N. J., Bonthron, D. T. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. Biochem. Biophys. Res. Commun. 242: 407-412, 1998. [PubMed: 9446808] [Full Text: https://doi.org/10.1006/bbrc.1997.7977]