Entry - *602881 - PHD FINGER PROTEIN 1; PHF1 - OMIM

 
 
* 602881

PHD FINGER PROTEIN 1; PHF1


Alternative titles; symbols

POLYCOMBLIKE, DROSOPHILA, HOMOLOG OF, 1; PCL1
PCL, DROSOPHILA, HOMOLOG OF, 1


HGNC Approved Gene Symbol: PHF1

Cytogenetic location: 6p21.32     Genomic coordinates (GRCh38): 6:33,410,412-33,416,439 (from NCBI)


TEXT

▼ Cloning and Expression

The 'Polycomb' group (PcG) of genes in Drosophila is required for the maintenance of repression of a number of key developmental regulatory genes. PcG proteins are thought to form a multimeric complex that modifies local chromatin structure and establishes a heritable repression state at particular loci. By carrying out BLAST searches, Coulson et al. (1998) identified a human cDNA, called PHF1, that was similar to the Drosophila 'Polycomblike' (Pcl) gene. They used the cDNA to screen a placenta library and isolated cDNAs containing the complete coding region of PHF1. The predicted 462-amino acid protein contains 2 PHD fingers. Northern blot analysis revealed that PHF1 is expressed as 2.6- and 3-kb transcripts in various tissues.


▼ Mapping

By fluorescence in situ hybridization, Coulson et al. (1998) mapped the PHF1 gene to 6p21.3.


▼ REFERENCES

  1. Coulson, M., Robert, S., Eyre, H. J., Saint, R. The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster. Genomics 48: 381-383, 1998. [PubMed: 9545646, related citations] [Full Text]


Creation Date:
Rebekah S. Rasooly : 7/23/1998
Edit History:
mgross : 03/27/2007
carol : 11/30/2005
alopez : 7/23/1998

* 602881

PHD FINGER PROTEIN 1; PHF1


Alternative titles; symbols

POLYCOMBLIKE, DROSOPHILA, HOMOLOG OF, 1; PCL1
PCL, DROSOPHILA, HOMOLOG OF, 1


HGNC Approved Gene Symbol: PHF1

Cytogenetic location: 6p21.32     Genomic coordinates (GRCh38): 6:33,410,412-33,416,439 (from NCBI)


TEXT

Cloning and Expression

The 'Polycomb' group (PcG) of genes in Drosophila is required for the maintenance of repression of a number of key developmental regulatory genes. PcG proteins are thought to form a multimeric complex that modifies local chromatin structure and establishes a heritable repression state at particular loci. By carrying out BLAST searches, Coulson et al. (1998) identified a human cDNA, called PHF1, that was similar to the Drosophila 'Polycomblike' (Pcl) gene. They used the cDNA to screen a placenta library and isolated cDNAs containing the complete coding region of PHF1. The predicted 462-amino acid protein contains 2 PHD fingers. Northern blot analysis revealed that PHF1 is expressed as 2.6- and 3-kb transcripts in various tissues.


Mapping

By fluorescence in situ hybridization, Coulson et al. (1998) mapped the PHF1 gene to 6p21.3.


REFERENCES

  1. Coulson, M., Robert, S., Eyre, H. J., Saint, R. The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster. Genomics 48: 381-383, 1998. [PubMed: 9545646] [Full Text: https://doi.org/10.1006/geno.1997.5201]


Creation Date:
Rebekah S. Rasooly : 7/23/1998

Edit History:
mgross : 03/27/2007
carol : 11/30/2005
alopez : 7/23/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 29, 2024