Alternative titles; symbols
HGNC Approved Gene Symbol: MLNR
Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,220,338-49,222,377 (from NCBI)
The growth hormone secretagogue receptor (GHSR; 601898) is a G protein-coupled receptor (see 601805) found in the pituitary gland and brain that is involved in the control of growth hormone (139250) release. McKee et al. (1997) identified 2 human genes related to GHSR: GPR38 and GPR39 (602886). The predicted 438-amino acid GPR38 protein contains the 7 transmembrane domains characteristic of G protein-coupled receptors. The amino acid sequences of GPR38 and GHSR are 52% identical. RNase protection studies revealed that GPR38 is expressed only in thyroid, stomach, and bone marrow.
Feighner et al. (1999) identified GPR38 as the motilin (158270) receptor and renamed it MTLR1. Two splice variants, which result in 2 different peptides, were named MTLR1A and MTLR1B. The motilin receptor is expressed in enteric neurons of the human duodenum and colon.
Feighner et al. (1999) demonstrated that the macrolide antibiotic erythromycin interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human gastrointestinal tract.
By computerized sequence analysis, McKee et al. (1997) determined that the GPR38 gene contains 2 exons.
By fluorescence in situ hybridization, McKee et al. (1997) mapped the GPR38 gene to 13q14-q21.
Feighner, S. D., Tan, C. P., McKee, K. K., Palyha, O. C., Hreniuk, D. L., Pong, S.-S., Austin, C. P., Figueroa, D., MacNeil, D., Cascieri, M. A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O'Neill, G., Van Der Ploeg, L. H. T., Evans, J., Patchett, A. A., Smith, R. G., Howard, A. D. Receptor for motilin identified in the human gastrointestinal system. Science 284: 2184-2188, 1999. [PubMed: 10381885] [Full Text: https://doi.org/10.1126/science.284.5423.2184]
McKee, K. K., Tan, C. P., Palyha, O. C., Liu, J., Feighner, S. D., Hreniuk, D. L., Smith, R. G., Howard, A. D., Van der Ploeg, L. H. T. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics 46: 426-434, 1997. [PubMed: 9441746] [Full Text: https://doi.org/10.1006/geno.1997.5069]