Entry - *602930 - REX4 HOMOLOG, 3-PRIME,5-PRIME-EXONUCLEASE; REXO4 - OMIM

 
 
* 602930

REX4 HOMOLOG, 3-PRIME,5-PRIME-EXONUCLEASE; REXO4


Alternative titles; symbols

RNA EXONUCLEASE 4, S. CEREVISIAE, HOMOLOG OF
REX4, S. CEREVISIAE, HOMOLOG OF; REX4
PREVENTS MITOTIC CATASTROPHE 2, XENOPUS, HOMOLOG OF; XPMC2H


HGNC Approved Gene Symbol: REXO4

Cytogenetic location: 9q34.2     Genomic coordinates (GRCh38): 9:133,406,058-133,418,172 (from NCBI)


TEXT

▼ Cloning and Expression

XPMC2 is a Xenopus gene identified on the basis of its ability to correct a mitotic defect in S. pombe. Using an exon trapping strategy, Kwiatkowska et al. (1997) identified a human homolog of XPMC2 within a BAC from chromosomal region 9q34. The gene, which they designated XPMC2H, encodes a predicted 422-amino acid protein. Like the Xenopus protein, XPMC2H is a basic protein, with a pI of 10.6, and contains a nuclear localization signal and potential CDC2 kinase (116940) sites. The 2 protein sequences are 52% identical.


▼ Gene Structure

The XPMC2H gene contains 8 exons (Kwiatkowska et al., 1997).


▼ Mapping

Kwiatkowska et al. (1997) mapped the XPMC2H gene to chromosome 9q34.


▼ REFERENCES

  1. Kwiatkowska, J., Slomski, R., Jozwiak, S., Short, M. P., Kwiatkowski, D. J. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Genomics 44: 350-354, 1997. [PubMed: 9325058, related citations] [Full Text]


Creation Date:
Rebekah S. Rasooly : 8/4/1998
Edit History:
carol : 03/27/2020
carol : 02/18/2010
wwang : 9/28/2005
alopez : 8/4/1998

* 602930

REX4 HOMOLOG, 3-PRIME,5-PRIME-EXONUCLEASE; REXO4


Alternative titles; symbols

RNA EXONUCLEASE 4, S. CEREVISIAE, HOMOLOG OF
REX4, S. CEREVISIAE, HOMOLOG OF; REX4
PREVENTS MITOTIC CATASTROPHE 2, XENOPUS, HOMOLOG OF; XPMC2H


HGNC Approved Gene Symbol: REXO4

Cytogenetic location: 9q34.2     Genomic coordinates (GRCh38): 9:133,406,058-133,418,172 (from NCBI)


TEXT

Cloning and Expression

XPMC2 is a Xenopus gene identified on the basis of its ability to correct a mitotic defect in S. pombe. Using an exon trapping strategy, Kwiatkowska et al. (1997) identified a human homolog of XPMC2 within a BAC from chromosomal region 9q34. The gene, which they designated XPMC2H, encodes a predicted 422-amino acid protein. Like the Xenopus protein, XPMC2H is a basic protein, with a pI of 10.6, and contains a nuclear localization signal and potential CDC2 kinase (116940) sites. The 2 protein sequences are 52% identical.


Gene Structure

The XPMC2H gene contains 8 exons (Kwiatkowska et al., 1997).


Mapping

Kwiatkowska et al. (1997) mapped the XPMC2H gene to chromosome 9q34.


REFERENCES

  1. Kwiatkowska, J., Slomski, R., Jozwiak, S., Short, M. P., Kwiatkowski, D. J. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Genomics 44: 350-354, 1997. [PubMed: 9325058] [Full Text: https://doi.org/10.1006/geno.1997.4874]


Creation Date:
Rebekah S. Rasooly : 8/4/1998

Edit History:
carol : 03/27/2020
carol : 02/18/2010
wwang : 9/28/2005
alopez : 8/4/1998



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 5, 2024