HGNC Approved Gene Symbol: DRG2
Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,087,948-18,107,969 (from NCBI)
Using a subtractive hybridization strategy, Schenker et al. (1994) identified embryonic lung fibroblast cDNAs whose expression was selectively repressed in SV40-transformed cells. One cDNA encoded a predicted 364-amino acid protein that was designated DRG2. DRG2 contains the 5 sequence motifs that are conserved in all GTP-binding proteins. Northern blot analysis detected DRG2 expression as a major 2-kb and a minor 1.5-kb transcript in various tissues. The shorter mRNA appeared to result from use of an alternative polyadenylation site.
By fluorescence in situ hybridization, Schenker and Trueb (1997) mapped the DRG2 gene to 17p13-p12. Vlangos et al. (2000) mapped the DRG2 gene to 17p11.2 within the Smith-Magenis syndrome critical region by somatic cell hybrid analysis.
Schenker, T., Lach, C., Kessler, B., Calderara, S., Trueb, B. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts. J. Biol. Chem. 269: 25447-25453, 1994. [PubMed: 7929244]
Schenker, T., Trueb, B. Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13-p12 by in situ hybridization. Cytogenet. Cell Genet. 79: 274-275, 1997. [PubMed: 9605870] [Full Text: https://doi.org/10.1159/000134741]
Vlangos, C. N., Das, P., Patel, P. I., Elsea, S. H. Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval. Cytogenet. Cell Genet. 88: 283-285, 2000. [PubMed: 10828610] [Full Text: https://doi.org/10.1159/000015539]