Alternative titles; symbols
HGNC Approved Gene Symbol: CDH18
Cytogenetic location: 5p14.3 Genomic coordinates (GRCh38): 5:19,471,296-20,575,713 (from NCBI)
Cadherins, a family of calcium-dependent cell-cell adhesion molecules, mediate neural cell-cell interactions and may play important roles in neural development. Cadherins are transmembrane proteins that associate with the cytoplasmic proteins alpha-catenin (e.g., 116805), beta-catenin (116806), plakoglobin (173325), and p120, all of which regulate the functions of cadherins.
To isolate cDNAs encoding proteins that interact with beta-catenin, Shibata et al. (1997) screened a human adult brain cDNA expression library with recombinant beta-catenin protein. They identified a cDNA with high sequence homology to cadherin molecules and designated it cadherin-14 (CDH14), which has been renamed cadherin-18 (CDH18). Comparison of the deduced 790-amino acid CDH18 sequence with the sequences of other cadherins revealed that CDH18 is more closely related to type 2 cadherins than to type 1 cadherins, with the N-terminal regions of CDH18 and CDH12 (600562) showing particularly high amino acid similarity. Northern blot analysis of human tissues detected 9.7-, 5.5-, and 3.9-kb CDH18 transcripts specifically in the central nervous system; CDH18 expression was also found in small-cell lung carcinoma cell lines, which have neuroectodermal cell phenotypes.
By radiation hybrid analysis, Chalmers et al. (1999) identified a cluster of cadherin genes on chromosome 5p that included CDH18, CDH12 (600562), and CDH6 (603007). CDH18 was linked to D5S1746 on chromosome 5p15.2-p15.1.
Chalmers, I. J., Hofler, H., Atkinson, M. J. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics 57: 160-163, 1999. [PubMed: 10191097] [Full Text: https://doi.org/10.1006/geno.1998.5717]
Shibata, T., Shimoyama, Y., Gotoh, M., Hirohashi, S. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. J. Biol. Chem. 272: 5236-5240, 1997. [PubMed: 9030594] [Full Text: https://doi.org/10.1074/jbc.272.8.5236]