(, DHFR)



EC 1.5.1.3 5,6,7,8-TETRAHYDROFOLATE:NADP('+) OXIDOREDUCTASE

: , dihydrofolate reductase , tetrahydrofolate dehydrogenase .

: DHF + NADPH + H(+) = THF + NADP(+) FOLATE + NADPH + H(+) = DHF + NADP(+)

(The enzyme from animals and some micro-organisms also slowly reduces folate to THF) GEM: $ 05q1/DHFR MIM: 126060

: ( megaloblastic anemia ; dihydrofolate reductase deficiensy ) - - .

: - 30 kb; 6 5 ( 362 bp 12kb). - 3.8 kb; - 0.8 1.0 kb.

( .., .., .., 1991 )

HGM/10.5, DHFR q11.2-13.2. Anagnou (1988) Funanage (1984), - 5 in situ) DHFR q11.1-13.2 ( , q22). Maurer (1985) 5q DHFR q23. , 5q23 . HGM/10.5 : GEM: 18^/DHFRP1, GEM: 06^/DHFRP2, GEM: 03^/DHFRP4. ( "^" , ). 3- , DHFR- : GEM: 10q/DHFRL1 (Wolman, 1983; Meltzer, 1985) GEM: 05q23/DHFRL2 (Maurer, 1984, 1985).

:

Chen et al, 1982 Chen et al, 1984

Yang et al, 1984 Masters, Attardi, 1983

Shimada et al, 1983 Shimada, 1985 Shimada et al, 1986

Maurer et al, 1984 Maurer et al, 1985 Maurer et al, 1987

Srimatkananda, 1983 Wolman et al, 1983

Anagnou et al, 1984 Anagnou et al, 1985

Anagnou et al, 1987 Anagnou, 1988

Funanage, 1984 Meltzer et al, 1985 Feder et al, 1987 Gilliam et al, 1989 Erbe R.W., 1975 Tauro et al, 1976

:

  • (2.7.4.6)
  • .
  • : ,
  • : ,
  • :
  • ( ):
  • E2F/DP
  • ,