Рис. SPTA seq.
Нуклеотидная и амнокислотная последовательности гена альфа спектрина tgtcgattg tgtatggctgatgggattctaggaccaagcaagaggttttttttttttcccccacatac ttaacgtttctatatttctatttgaattcgactggacagttccatttgaattatttctc tctctctctctctctctctgacacattttatcttgccaggttctaaacctttaggaaaa atg gag caa ttt cca aag gaa acc gtt gtg gag agc agt ggg cca met glu gln phe pro lys glu thr val val glu ser ser gly pro 15 aag gtt ttg gaa aca gca gaa gag atc cag gag agg cgt cag gaa lys val leu glu thr ala glu glu ile gln glu arg arg gln glu 30 gtg ttg act cgg tat caa agt ttc aag gag cgg gtt gct gag agg val leu thr arg tyr gln ser phe lys gln arg val ala glu arg 45 ggt cag aag ctt gag gat tcc tat cac tta caa gtt ttc aag cga gly gln lys leu glu asp ser tyr his leu gln val phe lys arg 60 gat gca gat gat ctg ggg aag tgg atc atg gag aaa gtc aat atc asp ala asp asp leu gly lys trp ile met glu lys val asn ile 75 tta acc gat aag agc tat gaa gac cca act aat ata cag ggg aaa leu the asp lys ser tyr glu asp pro thr asn ile gln gly lys 90 tat cag aag cat caa tcc ctt gaa gca gag gtg caa acg aaa tca tyr gln lys his gln ser leu glu ala glu val gln thr lys ser 105 aga ctc atg tct gaa ctg gaa aaa aca agg gaa gaa cga ttt acc arg leu met ser glu leu glu lys thr arg glu glu arg phe thr 120 atg ggt cat tct gcc cac gaa gaa acg aag gcc cat ata gag gag met gly his ser ala his glu glu thr lys ala his ile glu glu 135 cta cgc cac ctg tgg gac ctg ctg tta gag ctg acc ctg gag aag leu arg his leu trp asp leu leu leu glu leu thr leu glu lys 150 ggt gac cag ttg ctg cgg gcc ctg aag ttc cag cag tat gta cag gly asp gln leu leu arg ala leu lys phe gln gln tyr val gln 165 gag tgt gct gac atc tta gag tgg att gga gac aag gag gct ata glu cys ala asp ile leu glu trp ile gly asp lys glu ala ile 180 gcg aca tca gtg gag cta ggt gaa gac tgg gag cgc acc gaa gtt ala thr ser val glu leu gly glu asp trp glu arg thr glu val 195 ctg cat aag aaa ttt gaa gac ttc caa gtg gag ctg gta gct aaa leu his lys lys phe glu asp phe gln val glu leu val ala lys 210 gaa ggg aga gtt gtt gaa gtg aac caa tat gcc aat gag tgt gcc glu gly arg val val glu val asn gln tyr ala asn glu cys ala 225 gag gaa aac cat cct gac cta ccc tta att cag tct aag caa aat glu glu asn his pro asp leu pro leu ile gln ser lys gln asn 240 gag gtg aat gct gcc tgg gag cgc ctt cgt ggt ttg gct ctc cag glu val asn ala ala trp glu arg leu arg glu leu ala leu gln 255 aga cag aaa gct ctg tcc aat gct gca aac tta caa cga ttc aaa arg gln lys ala leu ser asn ala ala asn leu gln arg phe lys 270 agg gat gtg act gaa gcc atc cag tgg atc aag gag aag gaa cct arg asp val thr glu ala ile gln trp ile lys glu lys glu pro 285 gta ctc acc tct gag gac tat ggc aaa gac ctt gtt gcc tct gaa val leu thr ser glu asp tyr gly lys asp leu val ala ser glu 300 gga ctg ttt cac agc cac aag gga ctt gag aga aat ctt gca gtc gly leu phe his ser his lys gly leu glua sp asn leu ala val 315 atg agt gac aag gtg aag gag tta tgt gct aaa gca gag aag ctg met ser asp lys val lys glu leu cys ala lys ala glu lys leu 330 aca ctt tcc cat cct tca gat gca cct cag atc cag gag atg aaa thr leu ser his pro ser asp ala pro gln ile gln glu met lys 345 gaa gat ctg gtc tcc agc tgg gag cat att cgt gcc ctg gcc acc glu asp leu val ser ser trp glu his ile arg ala leu ala thr 360 agc aga tat gaa aaa ctg cag gct act tat tgg tac cat cga ttt ser arg tyr glu lys leu gln ala thr tyr trp tyr his arg phe 375 tca tct gac ttt gat gaa ctc tca ggc tgg atg aac gag aag act ser ser asp phe asp glu leu ser gly trp met asn glu lys thr 390 gct gcg atc aat gct gat gag ctg cca aca gat gtg gct ggt gga ala ala ile asn ala asp glu leu pro thr asp val ala gly gly 405 gaa gtt ctg ctg gac agg cat cag cag cat aag cat gag att gac glu val leu leu asp arg his gln gln his lys his glu ile asp 420 tct tac gat gac cga ttt caa tct gct gat gag act ggt caa gac ser tyr asp asp arg phe gln ser ala asp glu thr gly gln asp 435 ctc gtg aat gcc aat cat gaa gcc tct gat gaa gtt cgg gaa aag leu val asn ala asn his glu ala ser asp glu val arg glu lys 450 atg gaa ata ctt gac aac aac tgg act gcc ctg ctg gaa ctg tgg met glu ile leu asp asn asn trp thr ala leu leu glu leu trp 465 gac gag cgt cat cgt cag tat gag cag tgc ttg gac ttt cat ctc asp glu arg his arg gln tyr glu gln cys leu asp phe his leu 480 ttc tac aga gac agt gag caa gtg gac agt tgg atg agt aga caa phe tyr arg asp ser glu gln val asp ser trp met ser arg gln 495 gag gcc ttc ctg gaa aac gag gat ctg gga aac tca ctg ggc agt glu ala phe leu glu asn glu asp leu gly asn ser leu gly ser 510 gca gaa gcc ctt ctt cag aag cat gaa gac ttt gag gaa gcc ttt ala glu ala leu leu gln lys his glu asp phe glu glu ala phe 525 act gcc cag gaa gag aag atc ata act gta gac aag act gca acc thr ala gln glu glu lys ile ile thr val asp lys thr ala thr 540 aaa ttg att ggt gat gac cat tat gat tca gag aac atc aag gct lys leu ile gly asp asp his tyr asp ser glu asn ile lys ala 555 atc cgt gac ggc ctg tta gcc cgg cgg gat gcc cta cgt gaa aag ile arg asp gly leu leu ala arg arg asp ala leu arg glu lys 570 gct gcc act aga cgt aga ttg ctg aag gag tca ttg ctt ctg caa ala ala thr arg arg arg leu leu lys glu ser leu leu leu gln 585 aaa ctg tat gag gac tca gat gac cta aag aac tgg atc aac aag lys leu tyr glu asp ser asp asp leu lys asn trp ile asn lys 600 aag aaa aag ttg gca gat gat gaa gat tac aag gac ata cag aac lys lys lys leu ala asp asp glu asp tyr lys asp ile gln asn 615 ttg aag agc agg gtt caa aag cag caa gtc ttt gaa aag gag ttg leu lys ser arg val gln lys gln gln val phe glu lys glu leu 630 gca gtt aat aag acc cag ctg gaa aac ata cag aaa act ggc caa ala val asn lys thr gln leu glu asn ile gln lys thr gly gln 645 gag atg att gag ggt ggt cac tat gcc tct gac aat gtg acc act glu met ile glu gly gly his tyr ala ser asp asn val thr thr 660 cgt ctg agt gaa gtt gcc agc ctc tgg gag gag ttg ctg gag gct arg leu ser glu val ala ser leu trp glu glu leu leu glu ala 675 aca aaa cag aaa ggg acc cag ttg cat gag gcc aac cag cag ctg thr lys gln lys gly thr gln leu his glu ala asn gln gln leu 690 caa ttt gaa aat aat gca gaa gat ttg cag cgc tgg ctg gag gat gln phe glu asn asn ala glu asp leu gln arg trp leu glu asp 705 gtt gag tgg caa gtc acc tct gag gat tat ggg aaa ggc ctg gcc val glu trp gln val thr ser glu asp tyr gly lys gly leu ala 720 gag gta cag aat cga ctc agg aaa cac ggc ctc ctg gag tcg gct glu val gln asn arg leu arg lys his gly leu leu glu ser ala 735 gtg gct gct cgt cag gat cag gtg gat atc ctt aca gac ctg gct val ala ala arg gln asp gln val asp ile leu thr asp leu ala 750 gca tat ttt gaa gaa ata ggc cat cct gat tct aag gat ata agg ala tyr phe glu glu ile gly his pro asp ser lys asp ile arg 765 gca agg caa gag tcc ttg gta tgc cga ttt gaa gct ctg aaa gag ala arg gln glu ser leu val cys arg phe glu ala leu lys glu 780 cca ctg gcc acc cga aag aag aag ctc tta gac ctt ctc cat ctg pro leu ala thr arg lys lys lys leu leu asp leu leu his leu 795 cag ctg att tgt aga gac aca gag gat gag gag gcc tgg atc caa gln leu ile cys arg asp thr glu asp glu glu ala trp ile gln 810 gag act gaa ccc tca gct act tcc acc tac ctt gga aag gac ctg glu thr glu pro ser ala thr ser thr tyr leu gly lys asp leu 825 att gct tcc aaa aag ctt ctg aat agg cat aga gtc atc ctg gag ile ala ser lys lys leu leu asn arg his arg val ile leu glu 840 aac att gcc agc cat gaa cca cgc att caa gag ata aca gaa agg asn ile ala ser his glu pro arg ile gln glu ile thr glu arg 855 gga aac aaa atg gta gag gaa gga cac ttt gct gca gaa gat gtg gly asn lys met val glu glu gly his phe ala ala glu asp val 870 gcc tct agg gtc aag agt ttg aac cag aat atg gag tct ctc cgt ala ser arg val lys ser leu asn gln asn met glu ser leu arg 885 gct cga gct gct agg cga caa aat gat ctt gaa gcc aat gtc cag ala arg ala ala arg arg gln asn asp leu glu ala asn val gln 900 ttc cag cag tac ctg gct gac ctg cat gaa gca gaa aca tgg atc phe gln gln tyr leu ala asp leu his glu ala glu thr trp ile 915 aga gag aag gaa cct att gta gat aat act aac tat ggt gct gat arg glu lys glu pro ile val asp asn thr asn tyr gly ala asp 930 gaa gaa gca gct ggg gct ctt cta aag aag cat gag gcc ttt cta glu glu ala ala gly ala leu leu lys lys his glu ala phe leu 945 tta gat ctc aat tca ttt gga gac agt atg aaa gct ctg cgg aat leu asp leu asn ser phe gly asp ser met lys ala leu arg asn 960 cag gca aac gcc tgc cag caa caa cag gct gca cca gtg gag gga gln ala asn ala cys gln gln gln gln ala ala pro val glu gly 975 gtt gct gga gaa caa agg gtc atg gct tta tat gac ttc cag gcc val ala gly glu gln arg val met ala leu tyr asp phe gln ala 990 cgc agc ccc cga gaa gtc acc atg aag aaa ggt gat gtc tta acg arg ser pro arg glu val thr met lys lys gly asp val leu thr 1005 ctg ctc agt tcc atc aat aag gac tgg tgg aag gtg gaa gct gct leu leu set ser ile asn lys asp trp trp lys val glu ala ala 1020 gat cat cag ggc att gtc cca gct gtc tat gtc aga aga ctg gcc asp lis gln gly ile val pro ala val tyr val arg arg leu ala 1035 cac gat gag ttc ccg atg ctc cca cag cgg cga cga gaa gag cca his asp glu phe pro met leu pro gln arg arg arg glu glu pro 1050 gga aac atc acc cag cgc cag gag cag att gag aac caa tac cgc gly asn ile thr gln arg gln glu gln ile glu asn gln tyr arg 1065 tcc ctc ttg gat cgg gca gaa gaa cgc aga cgt cgt cta ttg caa ser leu leu asp arg ala glu glu arg arg arg arg leu leu gln 1080 cgt tat aat gaa ttt tta ttg gcc tat gag gca gga gac atg ctg arg tyr asn glu phe leu leu ala tyr glu ala gly asp met leu 1095 gaa tgg att caa gag aaa aag gca gaa aac act gga gtg gaa cta glu trp ile gln glu lys lys ala glu asn thr gly val glu leu 2010 gat gat gtt tgg gag ctg cag aaa aag ttt gat gag ttc caa aag asp asp val trp glu leu gln lys lys phe asp glu phe gln lys 2025 gat ttg aat acc aat gag cct cgg cta agg gat atc aac aag gta asp leu asn thr asn glu pro arg leu arg asp ile asn lys val 2040 gct gat gat cta cta ttt gaa gga ctt cta aca cca gaa gga gct ala asp asp leu leu phe glu gly leu leu thr pro glu gly ala 2055 caa atc cgg cag gaa ttg aat gcc cgc tgg ggt tct ttg cag agg gln ile arg gln glu leu asn ala arg trp gly ser leu gln arg 2070 ctt gca gat gaa cag cgg cag ctg ctg ggc agt gcc cat gct gtt leu ala asp glu gln arg gln leu leu gly ser ala his ala val 2085 gaa gtg ttt cac aga gaa gca gat gac acg aag gag cag att gag glu val phe his arg glu ala asp asp thr lys glu gln ile glu 2100 aag aaa tgc cag gcc ctc agt gct gca gac cct ggc tca gat ctg lys lys cys gln ala leu ser ala ala asp pro gly ser asp leu 2115 ttc agt gtt cag gct ctt cag cga cgg cat gag ggc ttt gaa agg phe ser val gln ala leu gln arg arg his glu gly phe glu arg 2130
Смотрите также: