Рис. SPTB seq.
Нуклеотидная и аминокислотная последовательности
гена бета спектрина (SPTB)
cgccacccccgggctcgggtggccccgcttcagtcc
cagggcagggatccttccatgaagactgaggcaggcggagctgctaagagcctgctgac
atg aca tcg gcc aca gag ttt gaa aat gtg ggc aac cag cca cct
met thr ser ala thr glu phe glu asn val gly asn gln pro pro 15
tac agc agg atc aat gcc cgc tgg gac gcc cca gac gac gag ctg
tyr ser arg ile asn ala arg trp asp ala pro asp asp glu leu 30
gat aat gac aat agc tca gcc agg ctc ttt gag agg tcc cgg ata
asp asm asp asn ser ser ala arg leu phe glu arg ser arg ile 45
aag gcc ttg gca gat gag cgg gaa gtt gtt cag aaa aag acc ttc
lys ala leu ala asp glu arg glu val val gln lys lys thr phe 60
acg aaa tgg gtg aac tcg cac ctg gct cga gtg tcc tgc cgc atc
thr lys trp val asn ser his leu ala arg val ser cys arg ile 75
acc gat ctc tac aag gac ctg cgg gat ggg cgc atg ctc atc aag
thr asp leu tyr lys asp leu arg asp gly arg met leu ile lys 90
ctg ctg gag gtg ctc tct gga gag atg ctg cca aag ccc acc aag
leu leu glu val leu ser gly glu met leu pro lys pro thr lys 105
ggg aag atg cgc atc cac tgc ctg gag aat gtg gac aag gct ctc
gly lys met arg ile his cys leu glu asn val asp lys ala leu 120
cag ttc ctc aag gag cag cgt gta cac ctg gag aac atg ggc tcc
gln phe leu lys glu gln arg val his leu glu asn met gly ser 135
cat gac att gta gat ggc aac cac cgc ctg gtc ctg ggc ctc atc
his asp ile val asp gly asn his arg leu val leu gly leu ile 150
tgg acc atc atc ctc cgc ttc cag att cag gac att gtg gtc caa
trp thr ile ile leu arg phe gln ilr gln asp ile val val gln 165
act cag gaa ggt cgt gaa aca cgc tca gcc aag gat gcg ttg ctg
thr gln glu gly arg glu thr arg ser ala lys asp ala leu leu 180
ttg tgg tgt cag atg aag acg gca ggc tac cct cat gtt aat gtc
leu trp cys gln met lys thr ala gly tyr pro his val asn val 195
acc aac ttt acc tcc agc tgg aag gat ggc ttg gcc ttt aat gcc
thr asn phe thr ser ser trp lys asp gly leu ala phe asn ala 210
ctg ata cac aag cac cgg ccc gac ctg atc gac ttt gat aag ctg
leu ile his lys his arg pro asp leu ile asp phe asp lys leu 225
aag gac tcc aat gcc cgg cac aac ctg gag cac gca ttc aat gtg
lys asp ser asn ala arg his asn leu glu his ala phe asn val 240
gct gag cgc cag ctg ggc atc atc ccg ctc ctc gac ccc gaa gat
ala glu arg gln leu gly ile ile pro leu leu asp pro glu asp 255
gtc ttt acg gaa aac cct gat gag aaa tcc atc atc acc tat gtg
val phe thr glu asn pro asp glu lys ser ile ile thr tyr val 270
gtg gcc ttt tac cac tac ttc tcc aag atg aag gtg ctg gca gtg
val ala phe tyr his tyr phe ser lys met lys val leu ala val 285
gag ggc aag cgt gtc ggc aag gtt att gac cat gcc att gag act
glu gly lys arg val gly lys val ile asp his ala ile glu thr 300
gag aag atg att gaa aag tac agc ggg cta gcc tcg gac ctg ctc
glu lys met ile glu lys tyr ser gly leu ala ser asp leu leu 315
acc tgg atc gag cag acc atc act gtc ctg aac agc cgc aag ttt
thr trp ile glu gln thr ile thr val leu asn ser arg lys phe 330
gcc aac tcg ctg acg ggc gtc cag cag cag ctg cag gcc ttc agc
ala asn ser leu thr gly val gln gln gln leu gln ala phe ser 345
acc tac cgc acc gtg gag aag ccg ccc aag ttt caa gag aag ggg
thr tyr arg thr val glu lys pro pro lys phe gln glu lys gly 360
aat ctg gaa gtt cta ctt ttt acc atc cag tcc cgg atg aga gcc
asn leu glu val leu leu phe thr ile gln ser arg met arg ala 375
aac aat cag aaa gtg tac aca ccc cac gat ggg aaa cta gtg tct
asn asn gln lys val tyr thr pro his asp gly lys leu val ser 390
gac atc aac agg gcc tgg gaa agc ctg gag gaa gct ggg tat cgg
asp ile asn arg ala trp glu ser leu glu glu ala gly tyr arg 405
cgg gag ctg gcc ctg aga aat gag ctc att cgg cag gag aag cta
arg glu leu ala leu arg asn glu leu ile arg gln glu lys leu 420
gag caa cta gcc cgg cgc ttt gac cgg aag gcc gca atg aga gag
glu gln leu ala arg arg phe asp arg lys ala ala met arg glu 435
acc tgg ctc aat gaa aac cag cgc ctc gtg gcc cag gat aac ttt
thr trp leu asn glu asn gln arg leu val ala gln asp asn phe 450
ggg tat gac ctg gca gct gtg gag gcc gcc aag aag aag cat gag
gly tyr asp leu ala ala val glu ala ala lys lys lys his glu 465
gcc atc gag acc gac acg gct gcc tac gag gag cgg gtg aga gcc
ala ile glu tht asp thr ala ala tyr glu glu arg val arg ala 480
ctg gag gac ctg gct cag gag ctg gag aaa gag aac tac cat gac
leu glu asp leu ala gln glu leu glu lys glu asn tyr his asp 505
cag aag cgc atc acg gcc cgc aag gac aat ata ctg cgc cta tgg
gln lys arg ile thr ala arg lys asp asn ile leu arg leu trp 520
agc tac ctg cag gag ctg ctg cag tcc cgg cgc cag agg ctc gag
ser tyr leu gln glu leu leu gln ser arg arg gln arg leu glu 535
acc acc ctg gca ctg cag aag ctc ttc cag gac atg ctg cac agc
thr thr leu ala leu gln lys leu phe gln asp met leu his ser 550
atc gac tgg atg gat gag atc aag gct cac ctc ttg tct gcc gag
ile asp trp met asp glu ile lys ala his leu leu ser ala glu 565
ttt ggg aag cac ttg ttg gag gtt gaa gac ctg cta cag aag cac
phe gly lys his leu leu glu val glu asp leu leu gln lys his 580
aag ttg atg gaa gct gac atc gcc atc caa ggg gac aaa gtg aag
lys leu met glu ala asp ile ala ile gln gly asp lys val lys 595
gcc atc acc gca gcc acc ctg aag ttc acc gag ggg aaa ggg tac
ala ile thr ala ala thr leu lys phe thr glu gly lys gly tyr 610
cag cct tgt gac ccc cag gtc atc cag gac cgc atg agc cac ttg
gln pro cys asp pro gln val ile gln asp arg met ser his leu 625
gag cag tgc ttt gag gag ctg agc aac atg gca gct ggc gca agg
glu gln cys phe glu glu leu ser asn met ala ala gly ala arg 640
acc caa ctg gag cag tcc aaa cga ctc tgg aag ttc ttc tgg gag
thr gln leu glu gln ser lys arg leu trp lys phe phe trp glu 655
atg gat gag gct gag agc tgg atc aag gag aag gag cag atc tat
met asp glu ala glu ser trp ile lys glu lys glu gln ile tyr 670
tct tcc ctg gac tat ggc aaa gac ctg acc agt gtg ctc atc tta
ser ser leu asp tyr gly lys asp leu trp ser val leu ile leu 685
cag cgc aag cac aag gcc ttt gag gat gag ctc cgt ggg ctg gat
gln arg lys his lys ala phe glu asp glu leu arg gly leu asp 700
gct cac ctg gag cag atc ttc cag gag gct cat ggc atg gtt gcg
ala his leu glu gln ile phe gln glu ala his gly met val ala 715
cgc aag cag ttt ggg cac ccg cag atc gag gcc cgc atc aag gag
arg lys gln phe gly his pro gln ile glu ala arg ile lys glu 730
gtg tcg gca cag tgg gac cag ctg aag gac ctg gct gcc ttc tgc
val ser ala gln trp asp gln leu lys asp leu ala ala phe cys 745
aag aag aac ctc cag gat gct gag aac ttt ttc cag ttc cag ggc
lys lys asn leu gln asp ala glu asn phe phe gln phe gln gly 760
gat gcg gat gac ctg aag gct tgg ctg caa gac gcc cac cgg ctg
asp ala asp asp leu lys ala trp leu gln asp ala his arg leu 775
ctc tct ggt gaa gat gtg ggg cag gac gaa ggg gcc acg cgg gcc
leu ser gly glu asp val gly gln asp glu gly ala thr arg ala 790
ctg ggg aaa aag cac aag gac ttc ctg gag gag ctg gag gag agc
leu gly lys lys his lys asp phe leu glu glu leu glu glu ser 805
cgt ggg gtg atg gag cac ctg gag cag cag gcc cag gga ttc ccc
arg gly val met glu his leu glu gln gln ala gln gly phe pro 820
gaa gag ttt cgg gat tcc cca gat gtg acc cat cgg ctg cag gcc
glu glu phe arg asp ser pro asp val thr his arg leu gln ala 835
ctg cgg gag ctc tac caa cag gtg gtg gcc cag gcg gac ctg cgt
leu arg glu leu tyr gln gln val val ala gln ala asp leu arg 850
cag cag agg ctg cag gaa gcc ctg gac ctg tac acg gtg ttc ggg
gln gln arg leu gln glu ala leu asp leu tyr thr val phe gly 865
gag aca gac gcc tgt gag ctg tgg atg gga gag aag gag aag tgg
glu thr asp ala cys glu leu trp met gly glu lys glu lys trp 880
ctg gcc gag atg gaa atg cca gac acc ctg gag gac ctg gag gtc
leu ala glu met glu met pro asp thr leu glu asp leu glu val 895
gtg cag cac agg ttc gac atc ctg gac cag gag atg aag acc ttg
val gln his arg phe asp ile leu asp gln glu met lys thr leu 910
atg act cag att gat ggt gtg aac ctc gct gcc aac agc ttg gta
met thr gln ile asp gly val asn leu ala ala asn ser leu val 925
gag agt ggc cac cca cgc agc agg gag gtg aag cag tac cag gac
glu ser gly his pro arg ser arg glu val lys gln tyr gln asp 940
cat ctg aac acc agg tgg cag gca ttt cag acc ctg gtg tcg gag
his leu asn thr arg trp gln ala phe gln thr leu val ser glu 955
cgg cgg gag gct gtg gac tca gcc ctc cga gtg cac aca cta tgc
arg arg glu ala val asp ser ala leu arg val his thr leu cys 970
gta gat tgc gag gag acc agc aag tgg atc acg gac aag aca aag
val asp cys glu glu thr ser lys trp ile thr asp lys thr lys 985
gta gtg gag tcc aca aaa gac ctg ggg cgg gac ctg gca ggt atc
val val glu ser thr lys asp leu gly arg asp leu ala gly ile 1000
atc gcc atc cag agg aag ttg tca ggg ctg gag cgt gac gtg gcc
ile ala ile gln arg lys leu ser gly leu glu arg asp val ala 1015
gcc atc cag gcc cgt gtg gat gcc ctg gag cgt gag tcc cag cag
ala ile gln ala arg val asp ala leu glu arg glu ser gln gln 1030
ctg atg gac tcg cac cct gag cag aag gag aat att ggt cag cgg
leu met asp ser his pro glu gln lys glu asn ile gly gln arg 1045
caa aaa cac ttg gag gag ctg tgg cag ggc ctg cag caa tcc ctg
gln lys his leu glu glu leu trp gln gly leu gln gln ser leu 1060
cag ggc cag gag gac ttg ctg ggg gaa gtc agc cag ctg cag gcc
gln gly gln glu asp leu leu gly glu val ser gln leu gln ala 1085
ttc ctg cag gat ctg gat gac ttc cag gcc tgg ctc tcc atc acc
phe leu gln asp leu asp asp phe gln ala trp leu ser ile thr 1100
cag aaa gct gtg gcc tct gag gac atg ccc gaa tcc ctc cca gag
gln lys ala val ala ser glu asp met pro glu ser leu pro glu 1115
gct gag cag ctc ctg cag cag cat gca ggt atc aag gat gag att
ala glu gln leu leu gln gln his ala gly ile lys asp glu ile 1130
gac ggg cac caa gac agc tac cag cgt gtt aag gag tct ggg gag
asp gly his gln asp ser tyr gln arg val lys glu ser gly glu 1145
aaa gtg atc caa ggc cag acg gac cca gag tat ctg ctt ctg ggc
lys val ile gln gly gln thr asp pro glu tyr leu leu leu gly 1160
cag cgg ctg gag ggc ctg gat act ggc tgg gat gcc ctg ggc agg
gln arg leu glu gly leu asp thr gly trp asp ala leu gly arg 1175
atg tgg gag agc cgc agc cac acc ctc gct cag tgc ctt ggc ttc
met trp glu ser arg ser his thr leu ala gln cys leu gly phe 1190
cag gag ttc cag aaa gat gcc aag cag gct gaa gcc atc ctc agc
gln glu phe gln lys asp ala lys gln ala glu ala ile leu ser 1205
aac cag gaa tac act ctg gct cac ttg gag ccc cca gac tcc ctg
asn gln glu tyr thr leu ala his leu glu pro pro asp ser leu 1220
gaa gct gca gag gct ggg atc cgg aag ttt gag gat ttc ttg ggg
glu ala ala glu ala gly ile arg lys phe glu asp phe leu gly 1235
tct atg gag aac aac cgg gat aag gtc ttg agt cct gtg gac tct
ser met glu asn asn arg asp lys val leu ser pro val asp ser 1250
gga aac aag ctg gta gct gag gga aac cta tac tca gac aag atc
gly asn lys leu val ala glu gly asn leu tyr ser asp lys ile 1265
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