Рис. F S seq
Нуклеотидная и аминокислотная последовательности
гена протеина S человека
ctg
gcgccgccgcgcagcacggctcagaccgaggcgcacaggctcgcagctccgcggcgccta
gcgctccggtccccgccgcgacgcgccaccgtccctgccggcgcctccgcgcgcttcgaa
-40
atg agg gtc ctg ggt ggg cgc tgc ggg gcg ttg ctg gcg tgt ctc
met arg val leu gly gly arg cys gly ala leu leu ala cys leu 15
ctc cta gtg ctt ccc gtc tca gag gca aac ttt ttg tca aag caa
leu leu val leu pro val ser glu ala asn phe leu ser lys gln 30
+1
cag gct tca caa gtc ctg gtt agg aag cgt cgt gca aat tct tta
gln ala ser gln val leu val arg lys arg arg ala asn ser leu 45
ctt gaa gaa acc aaa cag ggt aat ctt gaa aga gaa tgc atc gaa
leu glu glu thr lys gln gly asn leu glu arg glu cys ile glu 60
gaa ctg tgc aat aaa gaa gaa gcc agg gag gtc ttt gaa aat gac
glu leu cys asn lys glu glu ala arg glu val phe glu asn asp 75
ccg gaa acg gat tat ttt tat cca aaa tac tta gtt tgt ctt cgc
pro glu thr asp tyr phe tyr pro lys tyr leu val cys leu arg 90
tct ttt caa act ggg tta ttc act gct gca cgt cag tca act aat
ser phe gln thr gly leu phe thr ala ala arg gln ser thr asn 105
gct tat cct gac cta aga agc tgt gtc aat gcc att cca gac cag
ala tyr pro asp leu arg ser cys val asn ala ile pro asp gln 120
tgt agt cct ctg cca tgc aat gaa gat gga tat atg agc tgc aaa
cys ser pro leu pro cys asn glu asp gly tyr met ser cys lys 135
gat gga aaa gct tct ttt act tgc act tgt aaa cca ggt tgg caa
asp gly lys ala ser phe thr cys thr cys lys pro gly trp gln 150
gga gaa aag tgt gaa ttt gac ata aat gaa tgc aaa gat ccc tca
gly glu kys cys glu phe asp ile asn glu cys lys asp pro ser 165
aat ata aat gga ggt tgc agt caa att tgt gat aat aca cct gga
asn ile asn gly gly cys ser gln ile cys asp asn thr pro gly 180
agt tac cac tgt tcc tgt aaa aat ggt ttt gtt atg ctt tca aat
ser tyr his cys ser cys lys asn gly phe val met leu ser asn 195
aag aaa gat tgt aaa gat gtg gat gaa tgc tct ttg aag cca agc
lys lys asp cys lys asp val asp glu cys ser leu lys pro ser 210
att tgt ggc aca gct gtg tgc aag aac atc cca gga gat ttt gaa
ile cys gly thr ala val cys lys asn ile pro gly asp phe glu 225
tgt gaa tgc ccc gaa ggc tac aga tat aat ctc aaa tca aag tct
cys glu cys pro glu gly tyr arg tyr asn leu lys ser lys ser 240
tgt gaa gat ata gat gaa tgc tct gag aac atg tgt gct cag ctt
cys glu asp ile asp glu cys ser glu asn met cys ala gln leu 255
tgt gtc aat tac cct gga ggt tac act tgc tat tgt gat ggg aag
cys val asn tyr pro gly gly tyr thr cys tyr cys asp gly lys 270
aaa gga ttc aaa ctt gcc caa gat cag aag agt tgt gag gtt gtt
lys gly phe lys leu ala gln asp gln lys ser cys glu val val 295
tca gtg tgc ctt ccc ttg aac ctt gac aca aag tat gaa tta ctt
ser val cys leu pro leu asn leu asp thr lys tyr glu leu leu 310
tac ttg gcg gag cag ttt gca ggg gtt gtt tta tat tta aaa ttt
tyr leu ala glu gln phe ala gly val val leu tyr leu lys phe 325
cgt ttg cca gaa atc agc aga ttt tca gca gaa ttt gat ttc cgg
arg leu pro glu ile ser arg phe ser ala glu phe asp phe arg 340
aca tat gat tca gaa ggc gtg ata ctg tac gca gaa tct atc gat
thr tyr asp ser glu gly val ile leu tyr ala glu ser ilu asp 355
cac tca gcg tgg ctc ctg att gca ctt cgt ggt gga aag att gaa
his ser ala gln leu leu ile ala leu arg gly gly lys ile glu 370
gtt cag ctt aag aat gaa cat aca tcc aaa atc aca act gga ggt
val gln leu lys asn glu his thr ser lys ile thr thr gly gly 395
gat gtt att aat aat ggt cta tgg aat atg gtg tct gtg gaa gaa
asp val ile asn asn gly leu gln asn met val ser val glu glu 410
tta gaa cat agt att agc att aaa ata gct aaa gaa gct gtg atg
leu glu his ser ile ser ile lys ile ala arg glu ala val met 425
gat ata aat aaa cct gga ccc ctt ttt aag ccg gaa aat gga ttg
asp ile asn lys pro gly pro leu phe lys pro glu asn gly leu 440
ctg gaa acc aaa gta tac ttt gca gga ttc cct cgg aaa gtg gaa
leu gly thr lys val tyr phe ala gly phe pro arg lys val glu 455
agt gaa ctc att aaa ccg att aac cct cgt cta gat gga tgt ata
ser glu leu ile lys pro ile asn pro arg leu asp gly cys ile 470
cga agc tgg aat ttg atg aag caa gga gct tct gga ata aag gaa
arg ser gln asn leu met lys gln gly ala ser gly ile lys glu 485
att att caa gaa aaa caa aat aag cat tgc ctg gtt act gtg gag
ile ile gln glu lys gln asn lys his cys leu val thr val glu 500
aag ggc tcc tac tat cct ggt tct gga att gct caa ttt cac ata
lys gly ser tyr tyr pro gly ser gly ile ala gln phe his ile 515
gat tat aat aat gta tcc agt gct gag ggt tgg cat gta aat gtg
asp tyr asn asn val ser ser ala glu gly gln his val asn val 530
acc ttg aat att cgt cca tcc acg ggc act ggt gtt atg ctt gcc
thr leu asn ile arg pro ser thr gly thr gly val met leu ala 545
ttg gtt tct ggt aac aac aca gtg ccc ttt gct gtg tcc ttg gtg
leu val ser gly asn asn thr val pro phe ala val ser leu val 560
gac tcc acc tct gaa aaa tca cag gat att ctg tta tct gtt gaa
asp ser thr ser glu lys ser gln asp ile leu leu ser val glu 575
aat act gta ata tat cgg ata cag gcc cta agt cta tgt tcc gat
asn thr val ile tyr arg ile gln ala leu ser ley cys ser asp 590
caa caa tct cat ctg gaa ttt aga gtc aac aga aac aat ctg gag
gln gln ser his leu glu phe arg val asn arg asn asn leu asn 605
ttg tcg aca cca ctt aaa ata gaa acc atc tcc cat gaa gac ctt
leu ser thr pro leu lys ile glu thr ile ser his glu asp leu 620
caa aga caa ctt gcc gtc ttg gac aaa gca atg aaa gca aaa gtg
gln arg gln leu ala val leu asl lys ala met lys ala lys val 635
gcc aca tac ctg ggt ggc ctt cca gat gtt cca ttc agt gcc aca
ala thr tyr leu gly gly leu pro asp val pro phe ser ala thr 650
cca gtg aat gcc ttt tat aat ggc tgc atg gaa gtg aat att aat
pro val asn ala phe tyr asn gly cys met glu val asn ile asn 665
ggt gta cag ttg gat ctg gat gaa gcc att tct aaa cat aat gat
gly val gln leu asp leu asp glu ala ile ser lys his asn asp 680
att aga gct cac tca tgt cca tca gtt tgg aaa aag aca aag aat
ile arg ala his ser cys pro ser val gln lys lys thr lys asn 695
tct taa ggcatcttttctctgcttataataccttttccttgtgtgtaattatactt
ser ter
atgtttcaataacagctgaagggttttatttacaatgtgcagtctttgattattttgtgg
tcctttcctgggatttttaaaaggtcctttgtcaaggaaaaaaattctgttgtgatataa
atcacagtaaagaaattcttacttctcttgctatctaagaatagtgaaaaataacaattt
taaatttgaatttttttcctacaaatgacagtttcaatttttgtttgtaaaactaaattt
ttaattttatcatcatgaactagtgtctaaatacctatgtttttttcagaaagcaaggaa
gtaaactcaaacaaaagtgcgtgtaattaaatactattaatcataggcagatactatttt
gtttatgtttttgtttttttcctgatgaaggcagaagagatggtggtctattaaatatga
attgaatggagggtcctaatgccttatttcaaaacaattcctcagggggaccagctttgg
cttcatctttctcttgtgtggcttcacatttaaaccagtatctttattgaattagaaaac
aagtgggacatattttcctgagagcagcacaggaatcttcttcttggcagctgcagtctg
tcaggatgagatatcagattaggttggataggtggggaaatctgaagtgggtacattttt
taaattttgctgtgtgggtcacacaaggtctacattacaaaagacagaattcagggatgg
aaaggagaatgaacaaatgtgggagttcatagttttccttgaatccaacttttaattacc
agagtaagttgccaaaatgtgattgttgaagtacaaaaggaactatgaaaaccagaacaa
attttaacaaaaggacaaccacagagggatatagtgaatatcgtatcattgtaatcaaag
aagtaaggaggtaagattgccacgtgcctgctggtactgtgatgcatttcaagtggcagt
tttatcacgtttgaatctaccattcatagccagatgtgtatcagatgtttcactgacagt
ttttaacaataaattcttttcactgtattttatatcacttataataaatcggtgtataat
ctaaaa aaaa
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