Рис. F 9 seq
Нуклеотидная и аминокислотная
последовательности гена фактора коагуляции IХ (F lX)
-46
atg cag cgc gtg aac atg atc atg gca gaa tca cca ggc ctc atc
met gln arg val asn met ile met ala glu ser pro gly leu ile 15
acc atc tgc ctt tta gga tat cta ctc agt gct gaa tgt aca gtt
thr ile cys leu leu gly tyr leu leu ser ala glu cys thr val 30
ttt ctt gat cat gaa aac gcc aac aaa att ctg aat cgg cca aag
phe leu asp his glu asn ala asn lys ile leu asn arg pro lys 45
-1 +1
agg tat aat tca ggt aaa ttg gaa gag ttt gtt caa ggg aac ctt
arg tyr asn ser gly lys leu glu glu phe val gln gly asn leu 60
gag aga gaa tgt atg gaa gaa aag tgt agt ttt gaa gaa gca cga
glu arg glu cys met glu glu lys cys ser phe glu glu ala arg 75
gaa gtt ttt gaa aac act gaa aga aca act gaa ttt tgg aag cag
glu val phe glu asn thr glu arg thr thr glu phe trp lys gln 90
tat gtt gat gga gat cag tgt gag tcc aat cca tgt tta aat ggc
tyr val asp gly asp gln cys glu ser asn pro cys leu asn gly 105
ggc agt tgc aag gat gac att aat tcc tat gaa tgt tgg tgt ccc
gly ser cys lys asp asp ile asn ser tyr glu cys trp cys pro 120
ttt gga ttt gaa gga aag aac tgt gaa tta gat gta aca tgt aac
phe gly phe glu gly lys asn cys glu leu asp val thr cys asn 135
att aag aat ggc aga tgc gag cag ttt tgt aaa aat agt gct gat
ile lys asn gly arg cys glu gln phe cys lys asn ser ala asp 150
aac aag gtg gtt tgc tcc tgt act gag gga tat cga ctt gca gaa
asn lys val val cys ser cys thr glu gly tyr arg leu ala glu 165
aac cag aag tcc tgt gaa cca gca gtg cca ttt cca tgt gga aga
asn gln lys ser cys glu pro ala val pro phe pro cys gly arg 180
gtt tct gtt tca caa act tct aag ctc acc cgt gct gag act gtt
val ser val ser gln thr ser lys leu thr arg ala glu thr val 195
ttt cct gat gtg gac tat gta aat tct act gaa gct gaa acc att
phe pro asp val asp tyr val asn ser thr glu ala glu thr ile 210
ttg gat aac atc act caa agc acc caa tca ttt aat gac ttc act
leu asp asn ile thr gln ser thr gln ser phe asn asp phe thr 225
cgg gtt gtt ggt gga gaa gat gcc aaa cca ggt caa ttc cct tgg
arg val val gly gly glu asp ala lys pro gly gln phe pro trp 240
cag gtt gtt ttg aat ggt aaa gtt gat gca ttc tgt gga ggc tct
gln val val leu asn gly lys val asp ala phe cys gly gly ser 255
atc gtt aat gaa aaa tgg att gta act gct gcc cac tgt gtt gaa
ile val asn glu lys trp ile val thr ala ala his cys val glu 270
act ggt gtt aaa att aca gtt gtc gca ggt gaa cat aat att gag
thr gly val lys ile thr val val ala gly glu his asn ile glu 285
gag aca gaa cat aca gag caa aag cga aat gtg att cga att att
glu thr glu his thr glu gln lys arg asn val ile arg ile ile 300
cct cac cac aac tac aat gca gct att aat aag tac aac cat gac
pro his his asn tyr asn ala ala ile asn lys tyr asn his asp 315
att gcc ctt ctg gaa ctg gac gaa ccc tta gtg cta aac agc tac
ile ala leu leu glu leu asp glu pro leu val leu asn ser tyr 330
gtt aca cct att tgc att gct gac aag gaa tac acg aac atc ttc
val thr pro ile cys ile ala asp lys glu tyr thr asn ile phe 345
ctc aaa ttt gga tct ggc tat gta agt ggc tgg gga aga gtc ttc
leu lys phe gly ser gly tyr val ser gly trp gly arg val phe 360
cac aaa ggg aga tca gct tta gtt ctt cag tac ctt aga gtt cca
his lys gly arg ser ala leu val leu gln tyr leu arg val pro 375
ctt gtt gac cga gcc aca tgt ctt cga tct aca aag ttc acc atc
leu val asp arg ala thr cys leu arg ser thr lys phe thr ile 390
tat aac aac atg ttc tgt gct ggc ttc cat gaa gga ggt aga gat
tyr asn asn met phe cys ala gly phe his glu gly gly arg asp 405
tca tgt caa gga gat agt ggg gga ccc cat gtt act gaa gtg gaa
ser cys gln gly asp ser gly gly pro his val thr glu val glu 420
ggg acc agt ttc tta act gga att att agc tgg ggt gaa gag tgt
gly thr ser phe leu thr gly ile ile ser trp gly glu glu cys 435
gca atg aaa ggc aaa tat gga ata tat acc aag gta tcc cgg tat
ala met lys gly lys tyr gly ile tyr thr lys val ser arg tyr 450
gtc aac tgg att aag gaa aaa aca aag ctc act taa
val asn trp ile lys glu lys thr lys leu thr ter
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