Рис. F 13a seq


           Нуклеотидная и аминокислотная последовательности
                      гена фактора XIIIA человека.                        
                                            

   -1  +1
   ATG TCA GAA ACT TCC AGG ACC GCC TTT GGA GGC AGA AGA GCA GTT
   met ser glu thr ser arg thr ala phe gly gly arg arg ala val  15

   CCA CCC AAT AAC TCT AAT GCA GCG GAA GAT GAC CTG CCC ACA GTG
   pro pro asn asn ser asn ala ala gln asp asp leu pro thr val  30

   GAG CTT CAG GGC GTG GTG CCC CGG GGC GTC AAC CTG CAA GAG TTT
   glu leu gln gly val val pro arg gly val asn leu gln glu phe  45

   CTT AAT GTC ACG AGC GTT CAC CTG TTC AAG GAG AGA TGG GAC ACT
   leu asn val thr ser val his leu phe lys glu arg trp asp thr  60

   AAC AAG GTG GAC CAC CAC ACT GAC AAG TAT GAA AAC AAC AAG CTG
   asn lys val asp his his thr asp lys tyr glu asn asn lys leu  75

   ATT GTC CGC AGA GGG CAG TCT TTC TAT GTG CAG ATT GAC CTC AGT
   ile val arg arg gly gln ser phe tyr val gln ile asp leu ser  90

   CGT CCA TAT GAC CCC AGA AGG GAT CTC TTC AGG GTG GAA TAC GTC
   arg pro tyr asp pro arg arg asp leu phe arg val glu tyr val 105

   ATT GGT CGC TAC CCA CAG GAG AAC AAG GGA ACC TAC ATC CCA GTG
   ile gly arg tyr pro gln glu asn lys gly thr tyr ile pro val 120

   CCT ATA GTC TCA GAG TTA CAA AGT GGA AAG TGG GGG GCC AAG ATT
   pro ile val ser glu leu gln ser gly lys trp gly ala lys ile 135

   GTC ATG AGA GAG GAC AGG TCT GTG CGG CTG TCC ATC CAG TCT TCC
   val met arg glu asp arg ser val arg leu ser ile gln ser ser 150

   CCC AAA TGT ATT GTG GGG AAA TTC CGC ATG TAT GTT GCT GTC TGG
   pro lys cys ile val gly lys phe arg met tyr val ala val trp 165

   ACT CCC TAT GGC GTA CTT CGA ACC AGT CGA AAC CCA GAA ACA GAC
   thr pro tyr gly val leu arg thr ser arg asn pro glu thr asp 180

   ACG TAC ATT CTC TTC AAT CCT TGG TGT GAA GAT GAT GCT GTG TAT
   thr tyr ile leu phe asn pro trp cys glu asp asp ala val tyr 195

   CTG GAC AAT GAG AAA GAA AGA GAA GAG TAT GTC CTG AAT GAC ATC
   leu asp asn glu lys glu arg glu glu tyr val leu asn asp ile 210

   GGG GTA ATT TTT TAT GGA GAG GTC AAT GAC ATC AAG ACC AGA AGC
   gly val ile phe tyr gly glu val asn asp ile lys thr arg ser 225

   TGG AGC TAT GGT CAG TTT GAA GAT GGC ATC CTG GAC ACT TGC CTG
   trp ser tyr gly gln phe glu asp gly ile leu asp thr cys leu 240

   TAT GTG ATG GAC AGA GCA CAA ATG GAC CTC TCT GGA AGA GGG AAT
   tyr val met asp arg ala gln met asp leu ser gly arg gly asn 255

   CCC ATC AAA GTC AGC CGT GTG GGG TCT GCA ATG GTG AAT GCC AAA
   pro ile lys val ser arg val gly ser ala met val asn ala lys 270

   GAT GAC GAA GGT GTC CTC GTT GGA TCC TGG GAC AAT ATC TAT GCC
   asp asp glu gly val leu val gly ser trp asp asn ile tyr ala 285

   TAT GGC GTC CCC CCA TCG GCC TGG ACT GGA AGC GTT GAC ATT CTA
   tyr gly val pro pro ser ala trp thr gly ser val asp ile leu 300

   TTG GAA TAC CGG AGC TCT GAG AAT CCA GTC CGG TAT GGC CAA TGC
   leu glu tyr arg ser ser glu asn pro val arg tyr gly gln cys 315

   TGG GTT TTT GCT GGT GTC TTT AAC ACA TTT TTA CGA TGC CTT GGA
   trp val phe ala gly val phe asn thr phe leu arg cys leu gly 330

   ATA CCA GCA AGA ATT GTT ACC AAT TAT TTC TCT GCC CAT GAT AAT
   ile pro ala arg ile val thr asn tyr phe ser ala his asp asn 345

   GAT GCC AAT TTG CAA ATG GAC ATC TTC CTG GAA GAA GAT GGG AAC
   asp ala asn leu gln met asp ile phe leu glu glu asp gly asn 360

   GTG AAT TCC AAA CTC ACC AAG GAT TCA GTG TGG AAC TAC CAC TGC
   val asn ser lys leu thr lys asp ser val trp asn tyr his cys 375

   TGG AAT GAA GCA TGG ATG ACA AGG CCT GAC CTT CCT GTT GGA TTT
   trp asn glu ala trp met thr arg pro asp leu pro val gly phe 390

   GGA GGC TGG CAA GCT GTG GAC AGC ACC CCC CAG GAA AAT AGC GAT
   gly gly trp gln ala val asp ser thr pro gln glu asn ser asp 405

   GGC ATG TAT CGG TGT GGC CCC GCC TCG GTT CAA GCC ATC AAG CAC
   gly met tyr arg cys gly pro ala ser val gln ala ile lys his 420

   GGC CAT GTC TGC TTC CAA TTT GAT GCA CCT TTT GTT TTT GCA GAG
   gly his val cys phe gln phe asp ala pro phe val phe ala glu 435

   GTC AAC AGC GAC CTC ATT TAC ATT ACA GCT AAG AAA GAT GGC ACT
   val asn ser asp leu ile tyr ile thr ala lys lys asp gly thr 450

   CAT GTG GTG GAA AAT GTG GAT GCC ACC CAC ATT GGG AAA TTA ATT
   his val val glu asn val asp ala thr his ile gly lys leu ile 465

   GTG ACC AAA CAA ATT GGA GGA GAT GGC ATG ATG GAT ATT ACT GAT
   val thr lys gln ile gly gly asp gly met met asp ile thr asp 480

   ACT TAC AAA TTC CAA GAA GGT CAA GAA GAA GAG AGA TTG GCC CTA
   thr tyr lys phe gln glu gly gln glu glu glu arg leu ala leu 495

   GAA ACT GCC CTG ATG TAC GGA GCT AAA AAG CCC CTC AAC ACA GAA
   glu thr ala leu met tyr gly ala lys lys pro leu asn thr glu 510

   GGT GTC ATG AAA TCA AGG TCC AAC GTT GAC ATG GAC TTT GAA GTG
   gly val met lys ser arg ser asn val asp met asp phe glu val 525

   GAA AAT GCT GTG CTG GGA AAA GAC TTC AAG CTC TCC ATC ACC TTC
   glu asn ala val leu gly lys asp phe lys leu ser ile thr phe 540

   CGG AAC AAC AGC CAC AAC CGT TAC ACC ATC ACA GCT TAT CTC TCA
   arg asn asn ser his asn arg tyr thr ile thr ala tyr leu ser 555

   GCC AAC ATC ACC TTC TAC ACC GGG GTC CCG AAG GCA GAG TTC AAG
   ala asn ile thr phe tyr thr gly val pro lys ala glu phe lys 570

   AAG GAG ACG TTC GAC GTG ACG CTG GAG CCC TTG TCC TTC AAG AAA
   lys glu thr phe asp val thr leu glu pro leu ser phe lys lys 585

   GAG GCG GTG CTG ATC CAA GCC GGC GAG TAC ATG GGT CAG CTG CTG
   glu ala val leu ile gln ala gly glu tyr met gly gln leu leu 600

   GAA CAA GCG TCC CTG CAC TTC TTT GTC ACA GCT CGC ATC AAT GAG
   glu gln ala ser leu his phe phe val thr ala arg ile asn glu 615

   ACC AGG GAT GTT CTG GCC AAG CAA AAG TCC ACC GTG CTA ACC ATC
   thr arg asp val leu ala lys gln lys ser thr val leu thr ile 630

   CCT GAG ATC ATC ATC AAG GTC CGT GGC ACT CAG GTA GTT GGT TCT
   pro glu ile ile ile lys val arg gly thr gln val val gly ser 645

   GAC ATG ACT GTG ACA GTT CAG TTT ACC AAT CCT TTA AAA GAA ACC
   asp met thr val thr val gln phe thr asn pro leu lys glu thr 660

   CTG CGA AAT GTC TGG GTA CAC CTG GAT GGT CCT GGA GTA ACA AGA
   leu arg asn val trp val his leu asp gly pro gly val thr arg 675

   CCA ATG AAG AAG ATG TTC CGT GAA ATC CGG CCC AAC TCC ACC GTG
   pro met lys lys met phe arg glu ile arg pro asn ser thr val 690

   CAG TGG GAA GAA GTG TGC CGG CCC TGG GTC TCT GGG CAT CGG AAG
   gln trp glu glu val cys arg pro trp val ser gly his arg lys 705

   CTG ATA GCC AGC ATG AGC AGT GAC TCC CTG AGA CAT GTG TAT GGC
   leu ile ala ser met ser ser asp ser leu arg his val tyr gly 720

   GAG CTG GAC GTG CAG ATT CAA AGA CGA CCT TCC ATG TGA
   glu leu asp val gln ile gln arg arg pro ser met ter

Смотрите также:

  • Коагуляционный фактор XIII. Строение гена "а" cубъединицы фактора XIII