Рис. F 5 seq
Нуклеотидная и аминокислотная последовательности
гена фактора коагуляции V (F V)
-28
ATG TTC CCA GGC TGC CCA CGC CTC TGG GTC CTG GTG GTC TTG GGC
met phe pro gly cys pro arg leu trp val leu val val leu gly 15
ACC AGC TGG GTA GGC TGG GGG AGC CAA GGG ACA GAA GCG GCA CAG
trp ser trp val gly trp gly ser gln gly thr glu ala ala gln 30
CTA AGG CAG TTC TAC GTG GCT GCT CAG GGC ATC AGT TGG AGC TAC
leu arg glb phe tyr val ala ala gln gly ile ser trp ser tyr 45
CGA CCT GAG CCC ACA AAC TCA AGT TTG AAT CTT TCT GTA ACT TCC
arg pro glu pro thr asn ser ser leu asn leu ser val thr ser 60
TTT AAG AAA ATT GTC TAC AGA GAG TAT GAA CCA TAT TTT AAG AAA
phe lys lys ile val tyr arg glu tyr glu pro tyr phe lys lys 75
GAA AAA CCA CAA TCT ACC ATT TCA GGA CTT CTT GGG CCT ACT TTA
glu lys pro gln ser thr ile ser gly leu leu gly pro thr leu 90
TAT GCT GAA GTC GGA GAC ATC ATA AAA GTT CAC TTT AAA AAT AAG
tyr ala glu val gly asp ile ile lys val his phe lys asn lys 105
GCA GAT AAG CCC TTG AGC ATC CAT CCT CAA GGA ATT AGG TAC AGT
ala asp lys pro leu ser ile his pro gln gly ile arg tyr ser 120
AAA TTA TCA GAA GGT GCT TCT TAC CTT GAC CAC ACA TTC CCT GCA
lys leu ser glu gly ala ser tyr leu asp his thr phe pro ala 135
GAG AAG ATG GAC GAC GCT GTG GCT CCA GGC CGA GAA TAC ACC TAT
glu lys met asp asp ala val ala pro gly arg glu tyr thr tyr 150
GAA TGG AGT ATC AGT GAG GAC AGT GGA CCC ACC CAT GAT GAC CCT
glu trp ser ile ser glu asp ser gly pro thr his asp asp pro 165
CCA TGC CTC ACA CAC ATC TAT TAC TCC CAT GAA AAT CTG ATC GAG
pro cys leu thr his ile tyr tyr ser his glu asn leu ile glu 180
GAT TTC AAC TCT GGG CTG ATT GGG CCC CTG CTT ATC TGT AAA AAA
asp phe asn ser gly leu ile gly pro leu leu ile cys asn lys 195
GGG ACC CTA ACT GAG GGT GGG ACA CAG AAG ACG TTT GAC AAG CAA
gly thr leu thr glu gly gly thr gln lys thr phe asp lys gln 210
ATC GTG CTA CTA TTT GCT GTG TTT GAT GAA AGC AAG AGC TGG AGC
ile val leu leu phe ala val phe asp glu ser lys ser trp ser 225
CAG TCA TCA TCC CTA ATG TAC ACA GTC AAT GGA TAT GTG AAT GGG
gln ser ser ser leu met tyr thr val asn gly tyr val asn gly 240
ACA ATG CCA GAT ATA ACA GTT TGT GCC CAT GAC CAC ATC AGC TGG
thr met pro asp ile thr val cys ala his asp his ile ser trp 255
CAT CTG CTG GGA ATG AGC TCG GGG CCA GAA TTA TTC TCC ATT CAT
his leu leu gly met ser ser gly pro glu leu phe ser ile his 270
TTC AAC GGC CAG GTC CTG GAG CAG AAC CAT CAT AAG GTC TCA GCC
phe asn gly gln val leu glu gln asn his his lys val ser ala 285
ATC ACC CTT GTC AGT GCT ACA TCC ACT ACC GCA AAT ATG ACT GTG
ile thr leu val ser ala thr ser thr thr ala asn met thr val 300
GGC CCA GAG GGA AAG TGG ATC ATA TCT TCT CTC ACC CCA AAA CAT
gly pro glu gly lys trp ile ile ser ser leu thr pro lys his 315
TTG CAA GCT GGG ATG CAG GCT TAC ATT GAC ATT AAA AAC TGC CCA
leu gln ala gly met gln ala tyr ile asp ile lys asn cys pro 330
AAG AAA ACC AGG AAT CTT AAG AAA ATA ACT CGT GAG CAG AGG CGG
lys lys thr arg asn leu lys lys ile thr arg glu gln arg arg 345
CAC ATG AAG AGG TGG GAA TAC TTC ATT GCT GCA GAG GAA GTC ATT
his met lys arg trp glu tyr phe ile ala ala glu glu val ile 360
TGG GAC TAT GCA CCT GTA ATA CCA GCG AAT ATG GAC AAA AAA TAC
trp asp tyr ala phe val ile pro ala asn met asp lys lys tyr 375
AGG TCT CAG CAT TTG GAT AAT TTC TCA AAC CAA ATT GGA AAA CAT
arg ser gln his leu asp asn phe ser asn gln ile gly lys his 390
TAT AAG AAA GTT ATG TAC ACA CAG TAC GAA GAT GAG TCC TTC ACC
tyr lys lys val met tyr thr gln tyr glu asp glu ser phe tyr 405
AAA CAT ACA GTG AAT CCC AAT ATG AAA GAA GAT GGG ATT TTG GGT
lys his thr val asn pro asn met lys glu asp gly ile leu gly 420
CCT ATT ATC AGA GCC CAG GTC AGA GAC ACA CTC AAA ATC GTG TTC
pro ile ile arg ala gln val arg asp the leu lys ile val phe 435
AAA AAT ATG GCC AGC CGC CCC TAT AGC ATT TAC CCT CAT GGA GTG
lys asn met ala ser arg pro tyr ser ile tyr pro his gly val 450
ACC TTC TCG CCT TAT GAA GAT GAA GTC AAC TCT TCT TTC ACC TCA
thr phe ser pro tyr glu asp glu val asn ser ser phe thr ser 465
GGC AGG AAC AAC ACC ATG ATC AGA GCA GTT CAA CCA GGG GAA ACC
gly arg asn asn thr met ile arg ala val gln pro gly glu thr 480
TAT ACT TAT AAG TGG AAC ATC TTA GAG TTT GAT GAA CCC ACA GAA
tyr thr tyr lys trp asn ile leu glu phe asp glu pro thr glu 495
AAT GAT GCC CAG TGC TTA ACA AGA CCA TAC TAC AGT GAC GTG GAC
asn asp ala gln cys leu thr arg pro tyr tyr ser asp val asp 510
ATC ATG AGA GAC ATC GCC TCT GGG CTA ATA GGA CTA CTT CTA ATC
ile met arg asp ile ala ser gly leu ile gly leu leu leu ile 525
TGT AAG AGC AGA TCC CTG GAC AGG CGA GGA ATA CAG AGG GCA GCA
cys lys ser arg ser leu asp arg arg glu ile gln arg ala ala 540
GAC ATC GAA CAG CAG GCT GTG TTT GCT GTG TTT GAT GAG AAC AAA
asp ile glu gln gln ala val phe ala val phe asp glu asn lys 555
AGC TGG TAC CTT GAG GAC AAC ATC AAC AAG TTT TGT GAA AAT CCT
ser trp tyr leu glu asp asn ile asn lys phe cys glu asn pro 570
GAT GAG GTG AAA CGT GAT GAC CCC AAG TTT TAT GAA TCA AAC ATC
asp glu val lys arg asp asp pro lys phe tyr glu ser asn ile 595
ATG AGC ACT ATC AAT GGC TAT GTG CCT GAG AGC ATA ACT ACT CTT
met ser thr ile asn gly tyr val pro glu ser ile thr thr leu 610
GGA TTC TGC TTT GAT GAC ACT GTC CAG TGG CAC TTC TGT AGT GTG
gly phe cys [he asp asp thr val gln trp his phe cys ser val 625
GGG ACC CAG AAT GAA ATT TTG ACC ATC CAC TTC ACT GGG CAC TCA
gly thr gln asn glu ile leu thr ile his phe thr gly his ser 640
TTC ATC TAT GGA AAG AGG CAT GAG GAC ACC TTG ACC CTC TTC CCC
phe ile tyr gly lys arg his glu asp thr leu thr leu phe pro 655
ATG CGT GGA GAA TCT GTG ACG GTC ACA ATG GAT AAT GTT GGA ACT
met arg gly glu ser val thr val thr met asp asn val gly thr 680
TGG ATG TTA ACT TCC ATG AAT TCT AGT CCA AGA AGC AAA AAG CTG
trp met leu thr ser met asn ser ser pro arg ser lys lys leu 695
AGG CTG AAA TTC AGG GAT GTT AAA TGT ATC CCA GAT GAT GAT GAA
arg leu lys phe arg asp val lys cys ile pro asp asp asp glu 710
GAC TCA TAT GAG ATT TTT GAA CCT CCA GAA TCT ACA GTC ATG GCT
asp ser tyr glu ile phe glu pro pro glu ser thr val met ala 725
ACA CGG AAA ATG CAT GAT CGT TTA GAA CCT GAA GAT GAA GAG AGT
thr arg lys met his asp arg leu glu pro glu asp glu glu ser 740
GAT GCT GAC TAT GAT TAC CAG AAC AGA CTG GCT GCA GCA TTA GGA
asp ala asp tyr asp tyr gln asn arg leu ala ala ala leu gly 755
ATT AGG TCA TTC CGA AAC TCA TCA TTG AAC CAG GAA GAA GAA GAG
ile arg ser phe arg asn ser ser leu asn gln glu glu glu glu 770
TTC AAT CTT ACT GCC CTA GCT CTG GAG AAT GGC ACT GAA TTC GTT
phe asn leu thr ala leu ala leu glu gln gly thr glu phe val 785
TCT TCG AAC ACA GAT ATA ATT GTT GGT TCA AAT TAT TCT TCC CCA
ser ser asn thr asp ile ile val gly ser asn tyr ser ser pro 800
AGT AAT ATT AGT AAG TTC ACT GTC AAT AAC CTT GCA GAA CCT CAG
ser asn ile ser lys phe thr val asn asn leu ala glu pro gln 815
AAA GCC CCT TCT CAC CAA CAA GCC ACC ACA GCT GGT TCC CCA CTG
lys ala pro ser his gln gln ala thr thr ala gly ser pro leu 830
AGA CAC CTC ATT GGC AAG AAC TCA GTT CTC AAT TCT TCC ACA GCA
arg his leu ile gly lys asn ser val leu asn ser ser thr ala 845
GAG CAT TCC AGC CCA TAT TCT GAA GAC CCT ATA GAG GAT CCT CTA
glu his ser ser pro tyr ser glu asp pro ile glu asp pro leu 860
CAG CCA GAT GTC ACA GGG ATA CGT CTA CTT TCA CTT GGT GCT GGA
gln pro asp val thr gly ile arg leu leu ser leu gly ala gly 875
GAA TTC AGA AGT CAA GAA CAT GCT AAG CGT AAG GGA CCC AAG GTA
glu phe arg ser gln glu his ala lys arg lys gly pro lys val 890
GAA AGA GAT CAA GCA GCA AAG CAC AGG TTC TCC TGG ATG AAA TTA
glu arg asp gln ala ala lys his arg phe ser trp met lys leu 905
CTA GCA CAT AAA GTT GGG AGA CAC CTA AGC CAA GAC ACT GGT TCT
leu ala his lys val gly arg his leu ser gln asp thr gly ser 920
CCT TCC GGA ATG AGG CCC TGG GAG GAC CTT CCT AGC CAA GAC ACT
pro ser gly met arg pro trp glu asp leu pro ser gln asp thr 935
GGT TCT CCT TCC AGA ATG AGG CCC TGG GAG GAC CCT CCT AGT GAT
gly ser pro ser arg met arg pro trp glu asp pro pro ser asp 950
CTG TTA CTC TTA AAA CAA AGT AAC TCA TCT AAG ATT TTG GTT GGG
leu leu leu leu lys gln ser asn ser ser lys ile leu val gly 965
AGA TGG CAT TTG GCT TCT GAG AAA GGT AGC TAT GAA ATA ATC CAA
arg trp his leu ala ser glu lys gly ser tyr glu ile ile gln 980
GAT ACT GAT GAA GAC ACA GCT GTT AAC AAT TGG CTG ATC AGC CCC
asp thr asp glu asp thr ala val asn asn trp leu ile ser pro 995
CAG AAT GCC TCA CGT GCT TGG GGA GAA AGC ACC CCT CTT GCC AAC
gln asn ala ser arg ala trp gly glu ser thr pro leu ala asn 1100
AAG CCT GGA AAG CAG AGT GGC CAC CCA AAG TTT CCT AGA GTT AGA
lys pro gly lys gln ser gly his pro lys phe peo arg val arg 1115
CAT AAA TCT CTA CAA GTA AGA CAG GAT GGA GGA AAG AGT AGA CTG
his lys ser leu gln val arg gln asp gly gly lys ser arg leu 1130
AAG AAA AGC CAG TTT CTC ATT AAG ACA CGA AAA AAG AAA AAA GAG
lys lys ser gln phe leu ile lys thr arg lys lys lys lys glu 1145
AAG CAC ACA CAC CAT GCT CCT TTA TCT CCG AGG ACC TTT CAC CCT
lys his thr his his ala pro leu ser pro arg thr phe his pro 1160
CTA AGA AGT GAA GCC TAC AAC ACA TTT TCA GAA AGA AGA CTT AAG
leu arg ser glu ala tyr asn thr phe ser glu arg arg leu lys 1175
CAT TCG TTG GTG CTT CAT AAA TCC AAT GAA ACA TCT CTT CCC ACA
his ser leu val leu his lys ser asn glu thr ser leu pro thr 1190
GAC CTC AAT CAG ACA TTG CCC TCT ATG GAT TTT GGC TGG ATA GCC
asp leu asn gln thr leu pro ser met asp phe gly trp ile ala 2005
TCA CTT CCT GAC CAT AAT CAG AAT TCC TCA AAT GAC ACT GGT CAG
ser leu pro asp his asn gln asn ser ser asn asp thr gly gln 2020
GCA AGC TGT CCT CCA GGT CTT TAT CAG ACA GTG CCC CCA GAG GAA
ala ser cys pro pro gly leu tyr gln thr val pro pro glu glu 2035
CAC TAT CAA ACA TTC CCC ATT CAA GAC CCT GAT CAA ATG CAC TCT
his tyr gln thr phe pro ile gln asp pro asp gln met his ser 2050
ACT TCA GAC CCC AGT CAC AGA TCC TCT TCT CCA GAG CTC AGT GAA
thr ser asp pro ser his arf ser ser ser pro glu leu ser glu 2065
ATG CTT GAG TAT GAC CGA AGT CAC AAG TCC TTC CCC ACA GAT ATA
met leu glu tyr asp arg ser his lys ser phe pro thr asp ile 2080
AGT CAA ATG TCC CCT TCC TCA GAA CAT GAA GTC TGG CAG ACA GTC
ser gln met ser pro ser ser glu his glu val trp gln thr val 2095
ATC TCT CCA GAC CTC AGC CAG GTG ACC CTC TCT CCA GAA CTC AGC
ile ser pro asp leu ser gln val thr leu ser pro glu leu ser 2110
CAG ACA AAC CTC TCT CCA GAC CTC AGC CAC ACG ACT CTC TCT CCA
gln thr asn leu ser pro asp leu ser his thr thr leu ser pro 2125
GAA CTC ATT CAG AGA AAC CTT TCC CCA GCC CTC GGT CAG ATG CCC
glu leu ile gln arg asn leu ser pro ala leu gly gln met pro 2140
ATT TCT CCA GAC CTC AGC CAT ACA ACC CTT TCT CCA GAC CTC AGC
ile ser pro asp leu ser his thr thr leu ser pro asp leu ser 2155
CAT ACA ACC CTT TCT TTA GAC CTC AGC CAG ACA AAC CTC TCT CCA
his thr thr leu ser leu asp leu ser gln thr asn leu ser pro 2170
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