Рис. MPS II seq.
Нуклеотидная и аминокислотная последовательности
гена идуронатсульфатазы (iduronate 2-sulfatase)
(IDS) человека
ATG CCG CCA CCC CGG ACC GGC CGA GGC CTT CTC TGG CTG GGT CTG
met pro pro pro arg thr gly arg gly leu leu trp leu gly leu 15
GTT CTG AGC TCC GTC TGC GTC GCC CTC GGA TCC GAA ACG CAG GCC
val leu ser ser val cys val ala leu gly ser glu thr gln ala 30
AAC TCG ACC ACA GAT GCT CTG AAC GTT CTT CTC ATC ATC GTG GAT
asn ser thr thr asp ala leu asn val leu leu ile ile val asp 45
GAC CTG CGC CCC TCC CTG GGC TGT TAT GGG GAT AAG CTG GTG AGG
asp leu arg pro ser leu gly cys tyr gly asp lys leu val arg 60
TCC CCA AAT ATT GAC CAA CTG GCA TCC CAC AGC CTC CTC TTC CAG
ser pro asn ile asp gln leu ala ser his ser leu leu phe gln 75
AAT GCC TTT GCG CAG CAA GCA GTG TGC GCC CCG AGC CGC GTT TCT
asn ala phe ala gln gln ala val cys ala pro ser arg val ser 90
TTC CTC ACT GGC AGG AGA CCT GAC ACC ACC CGC CTG TAC GAC TTC
phe leu thr gly arg arg pro asp thr thr arg leu tyr asp phe 105
AAC TCC TAC TGG AGG GTG CAC GCT GGA AAC TTC TCC ACC ATC CCC
asn ser tyr trp arg val his ala gly asn phe ser thr ile pro 120
CAG TAC TTC AAG GAG AAT GGC TAT GTG ACC ATG TCG GTG GGA AAA
gln tyr phe lys glu asn gly tyr val thr met ser val gly lys 135
GTC TTT CAC CCT GGG ATA TCT TCT AAC CAT ACC GAT GAT TCT CCG
val phe his pro gly ile ser ser asn his thr asp asp ser pro 150
TAT AGC TGG TCT TTT CCA CCT TAT CAT CCT TCC TCT GAG AAG TAT
tyr ser trp ser phe pro pro tyr his pro ser ser glu lys tyr 165
GAA AAC ACT AAG ACA TGT CGA GGG CCA GAT GGA GAA CTC CAT GCC
glu asn thr lys thr cys arg gly pro asp gly glu leu his ala 180
AAC CTG CTT TGC CCT GTG GAT GTG CTG GAT GTT CCC GAG GGC ACC
asn leu leu cys pro val asp val leu asp val pro glu gly thr 195
TTG CCT GAC AAA CAG AGC ACT GAG CAA GCC ATA CAG TTG TTG GAA
leu pro asp lys gln ser thr glu gln ala ile gln leu leu glu 210
AAG ATG AAA ACG TCA GCC AGT CCT TTC TTC CTG GCC GTT GGG TAT
lys met lys thr ser ala ser pro phe phe leu ala val gly tyr 225
CAT AAG CCA CAC ATC CCC TTC AGA TAC CCC AAG GAA TTT CAG AAG
his lys pro his ile pro phe arg tyr pro lys glu phe gln lys 240
TTG TAT CCC TTG GAG AAC ATC ACC CTG GCC CCC GAT CCC GAG GTC
leu tyr pro leu glu asn ile thr leu ala pro asp pro glu val 255
CCT GAT GGC CTA CCC CCT GTG GCC TAC AAC CCC TGG ATG GAC ATC
pro asp gly leu pro pro val ala tyr asn pro trp met asp ile 270
AGG CAA CGG GAA GAC GTC CAA GCC TTA AAC ATC AGT GTG CCG TAT
arg gln arg glu asp val gln ala leu asn ile ser val pro tyr 285
GGT CCA ATT CCT GTG GAC TTT CAG CGG AAA ATC CGC CAG AGC TAC
gly pro ile pro val asp phe gln arg lys ile arg gln ser tyr 300
TTT GCC TCT GTG TCA TAT TTG GAT ACA CAG GTC GGC CGC CTC TTG
phe ala ser val ser tyr leu asp thr gln val gly arg leu leu 315
AGT GCT TTG GAC GAT CTT CAG CTG GCC AAC AGC ACC ATC ATT GCA
ser ala leu asp asp leu gln leu ala asn ser thr ile ile ala 330
TTT ACC TCG GAT CAT GGG TGG GCT CTA GGT GAA CAT GGA GAA TGG
phe thr ser asp his gly trp ala leu gly glu his gly glu trp 345
GCC AAA TAC AGC AAT TTT GAT GTT GCT ACC CAT GTT CCC CTG ATA
ala lys tyr ser asn phe asp val ala thr his val pro leu ile 360
TTC TAT GTT CCT GGA AGG ACG GCT TCA CTT CCG GAG GCA GGC GAG
phe tyr val pro gly arg thr ala ser leu pro glu ala gly glu 375
AAG CTT TTC CCT TAC CTC GAC CCT TTT GAT TCC GCC TCA CAG TTG
lys leu phe pro tyr leu asp pro phe asp ser ala ser gln leu 390
ATG GAG CCA GGC AGG CAA TCC ATG GAC CTT GTG GAA CTT GTG TCT
met glu pro gly arg gln ser met asp leu val glu leu val ser 405
CTT TTT CCC ACG CTG GCT GGA CTT GCA GGA CTG CAG GTT CCA CCT
leu phe pro thr leu ala gly leu ala gly leu gln val pro pro 420
CGC TGC CCC GTT CCT TCA TTT CAC GTT GAG CTG TGC AGA GAA GGC
arg cys pro val pro ser phe his val glu leu cys arg glu gly 435
AAG AAC CTT CTG AAG CAT TTT CGA TTC CGT GAC TTG GAA GAG GAT
lys asn leu leu lys his phe arg phe arg asp leu glu glu asp 450
CCG TAC CTC CCT GGT AAT CCC CGT GAA CTG ATT GCC TAT AGC CAG
pro tyr leu pro gly asn pro arg glu leu ile ala tyr ser gln 465
TAT CCC CGG CCT TCA GAC ATC CCT CAG TGG AAT TCT GAC AAG CCG
tyr pro arg pro ser asp ile pro gln trp asn ser asp lys pro 480
AGT TTA AAA GAT ATA AAG ATC ATG GGC TAT TCC ATA CGC ACC ATA
ser leu lys asp ile lys ile met gly tyr ser ile arg thr ile 495
GAC TAT AGG TAT ACT GTG TGG GTT GGC TTC AAT CCT GAT GAA TTT
asp tyr arg tyr thr val trp val gly phe asn pro asp glu phe 510
CTA GCT AAC TTT TCT GAC ATC CAT GCA GGG GAA CTG TAT TTT GTG
leu ala asn phe ser asp ile his ala gly glu leu tyr phe val 525
GAT TCT GAC CCA TTG CAG GAT CAC AAT ATG TAT AAT GAT TCC CAA
asp ser asp pro leu gln asp his asn met tyr asn asp ser gln 540
GGT GGA GAT CTT TTC CAG TTG TTG ATG CCT TGA
gly gly asp leu phe gln leu leu met pro ter
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