Рис. MPS IV A seq.
Нуклеотидная и аминокислотная последовательности гена
N-ацетилгалактозамин-6-сульфат-сульфатазы
galactosamine (N-acetyl)-6-sulphate sulphatase
(GALNS) человека
ATG GCG GCG GTT GTC GCG GCG ACG AGG TGG TGG CAG CTG TTG CTG
met ala ala val val ala ala thr arg trp trp gln leu leu leu 15
GTG CTC AGC GCC GCG GGG ATG GGG GCC TCG GGC GCC CCG CAG CCC
leu leu ser ala ala gly met gly ala ser gly ala pro gln pro 30
CCC AAC ATC CTG CTC CTG CTC ATG GAC GAC ATG GGA TGG GGT GAC
pro asn ile leu leu leu leu met asp asp met gly trp gly asp 45
CTC GGG GTG TAT GGA GAG CCC TCC AGA GAG ACC CCG AAT TTG GAC
leu gly val tyr gly glu pro ser arg glu thr pro asn leu asp 60
CGG ATG GCT GCA GAA GGG CTG CTT TTC CCA AAC TTC TAT TCT GCC
arg met ala ala glu gly leu leu phe pro asn phe tyr ser ala 75
AAC CCT CTG TGC TCG CCA TCG AGG GCG GCA CTG CTC ACA GGA CGG
asn pro leu cys ser pro ser arg ala ala leu leu thr gly arg 90
CTA CCC ATC CGC AAT GGC TTC TAC ACC ACC AAC GCC CAT GCC AGA
leu pro ile arg asn gly phe tyr thr thr asn ala his ala arg 105
AAC GCC TAC ACA CCG CAG GAG ATT GTG GGC GGC ATC CCA GAC TCG
asn ala tyr thr pro gln gln ile val gly gly ile pro asp ser 120
GAG CAG CTC CTG CCG GAG CTT CTG AAG AAG GCC GGC TAC GTC AGC
glu gln leu leu pro glu leu leu lys lys ala gly tyr val ser 135
AAG ATT GTC GGC AAG TGG CAT CTG GGT CAC AGG CCC CAG TTC CAC
lys ile val gly lys trp his leu gly his arg pro gln phe his 150
CCC CTG AAG CAC GGA TTT GAT GAG TGG TTT GGA TCC CCC AAC TGC
pro leu lys his gly phe asp glu trp phe gly ser pro asn cys 165
CAC TTT GGA CCT TAT GAC AAC AAG GCC AGG CCC AAC ATC CCT GTG
his phe gly pro tyr asp asn lys ala arg pro asn ile pro val 180
TAC AGG GAC TGG GAG ATG GTT GGC AGA TAT TAT GAA GAA TTT CCT
tyr arg asp trp glu met val gly arg tyr tyr glu glu phe pro 195
ATT AAT CTG AAG ACG GGG GAA GCC AAC CTC ACC CAG ATC TAC CTG
ile asn leu lys thr gly glu ala asn leu thr gln ile tyr leu 210
CAG GAA GCC CTG GAC TTC ATT AAG AGA CAG GCA CGG CAC CAC CCC
gln glu ala leu asp phe ile lys arg gln ala arg his his pro 225
TTT TTC CTC TAC TGG GCT GTC GAC GCC ACG CAT GCA CCC GTC TAT
phe phe leu tyr trp ala val asp ala thr his ala pro val tyr 240
GCC TCC AAA CCC TTC TTG GGC ACC AGT CAG CGA GGG CGG TAT GGA
ala ser lys pro phe leu gly thr ser gln arg gly arg tyr gly 255
GAC GCC GTC CGG GAG ATT GAT GAC AGC ATT GGG AAG ATA CTG GAG
asp ala val arg glu ile asp asp ser ile gly lys ile leu glu 270
CTC CTC CAA GAC CTG CAC GTC GCG GAC AAC ACC TTC GTC TTC TTC
leu leu gln asp leu his val ala asp asn thr phe val phe phe 285
ACG TCG GAC AAC GGC GCT GCC CTC ATT TCC GCC CCC GAA CAA GGT
thr ser asp asn gly ala ala leu ile ser ala pro glu gln gly 300
GGC AGC AAC GGC CCC TTT CTG TGT GGG AAG CAG ACC ACG TTT GAA
gly ser asn gly pro phe leu cys gly lys gln thr thr phe glu 315
GGA GGG ATG AGG GAG CCT GCC CTC GCA TGG TGG CCA GGG CAC GTC
gly gly met arg glu pro ala leu ala trp trp pro gly his val 330
ACT GCA GGC CAG GTG AGC CAC CAG CTG GGC AGC ATC ATG GAC CTC
thr ala gly gln val ser his gln leu gly ser ile met asp leu 345
TTC ACC ACC AGC CTG GCC CTT GCG GGC CTG ACG CCG CCC AGC GAC
phe thr thr ser leu ala leu ala gly leu thr pro pro ser asp 360
AGG GCC ATT GAT GGC CTC AAC CTC CTC CCC ACC CTC CTG CAG GGC
arg ala ile asp gly leu asn leu leu pro thr leu leu gln gly 375
CGG CTG ATG GAC AGG CCT ATC TTC TAT TAC CGT GGC GAC ACG CTG
arg leu met asp arg pro ile prp tyr tyr arg gly asp thr leu 390
ATG GCG GCC ACC CTC GGG CAG CAC AAG GCT CAC TTC TGG ACC TGG
met ala ala thr leu gly gln his lys ala his phe trp thr trp 405
ACC AAC TCC TGG GAG AAC TTC AGA CAG GGC ATT GAT TTC TGC CCT
thr asn ser trp glu asn phe arg gln gly ile asp phe cys pro 420
GGG CAG AAC GTT TCA GGG GTC ACA ACT CAC AAT CTG GAA GAC CAC
gly gln asn val ser gly val thr thr his asn leu glu asp his 435
ACG AAG CTG CCC CTG ATC TTC CAC CTG GGA CGG GAC CCA GGG GAG
thr lys leu pro leu ile phe his leu gly arg asp pro gly glu 450
AGG TTC CCC CTC AGC TTT GCC AGC GCC GAG TAC CAG GAG GCC CTC
arg phe pro leu ser phe ala ser ala glu tyr gln glu ala leu 465
AGC AGG ATC ACC TCG GTC GTC CAG CAG CAC CAG GAA GCC TTG GTC
ser arg ile thr ser val val gln gln his gln glu ala leu val 480
CCC GCG CAG CCC CAG CTC AAC GTG TGC AAC TGG GCG GTC ATG AAC
pro ala gln pro gln leu asn val cys asn trp ala val met asn 495
TGG GCA CCT CCG GGC TGT GAA AAG TTA GGG AAG TGT CTG ACA CCT
trp ala pro pro gly cys glu lys leu gly lys cys leu thr pro 510
CCA GAA TCC ATT CCC AAG AAG TGC CTC TGG TCC CAC TAG
pro glu ser ile pro lys lys cys leu trp ser his ter
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