Рис. MPS VI B seq.
Нуклеотидная и аминокислотная последовательности
гена арилсульфатазы В (arylsulphatase B)
(ARS) человека
ATG GGT CCG CGC GGC GCG GCG AGC TTG CCC CGA GGC CCC GGA CCT
met gly pro arg gly ala ala ser leu pro arg gly pro gly pro 15
CGG CGG CTG CTC CTC CCC GTC GTC CTC CCG CTG CTG CTG CTG CTG
arg arg leu leu leu pro val val leu pro leu leu leu leu leu 30
TTG TTG GCG CCG CCG GGC TCG GGC GCC GGG GCC AGC CGG CCG CCC
leu leu ala pro pro gly ser gly ala gly ala ser arg pro pro 45
CAC CTG GTC TTC TTG CTG GCA GAC GAC CTA GGC TGG AAC GAC GTC
his leu val phe leu leu ala asp asp leu gly trp asn asp val 60
GGC TTC CAC GGC TCC CGC ATC CGC ACG CCG CAC CTG GAC GCG CTG
gly phe his gly ser arg ile arg thr pro his leu asp ala leu 75
GCG GCC GGC GGG GTG CTC CTG GAC AAC TAC TAC ACG CAG CCG CTG
ala ala gly gly val leu leu asp asn tyr tyr thr gln pro leu 90
TGC ACG CCG TCG CGG AGC CAG CTG CTC ACT GGC CGC TAC CAG ATC
cys thr pro ser arg ser gln leu leu thr gly arg tyr gln ile 105
CGT ACA GGT TTA CAG CAC CAA ATA ATC TGG CCC TGT CAG CCC AGC
arg thr gly leu gln his gln ile ile trp pro cys gln pro ser 120
TGT GTT CCT CTG GAT GAA AAA CTC CTG CCC CAG CTC CTA AAA GAA
cys val pro leu asp glu lys leu leu pro gln leu leu lys glu 135
GCA GGT TAT ACT ACC CAT ATG GTC GGA AAA TGG CAC CTG GGA ATG
ala gly tyr thr thr his met val gly lys trp his leu gly met 150
TAC CGG AAA GAA TGC CTT CCA ACC CGC CGA GGA TTT GAT ACC TAC
tyr arg lys glu cys leu pro thr arg arg gly phe asp thr tyr 165
TTT GGA TAT CTC CTG GGT AGT GAA GAT TAT TAT TCC CAT GAA CGC
phe gly tyr leu leu gly ser glu asp tyr tyr ser his glu arg 180
TGT ACA TTA ATT GAC GCT CTG AAT GTC ACA CGA TGT GCT CTT GAT
cys thr leu ile asp ala leu asn val thr arg cys ala leu asp 195
TTT CGA GAT GGC GAA GAA GTT GCA ACA GGA TAT AAA AAT ATG TAT
phe arg asp gly glu glu val ala thr gly tyr lys asn met tyr 210
TCA ACA AAC ATA TTC ACC AAA AGG GCT ATA GCC CTC ATA ACT AAC
ser thr asn ile phe thr lys arg ala ile ala leu ile thr asn 225
CAT CCA CCA GAG AAG CCT CTG TTT CTC TAC CTT GCT CTC CAG TCT
his pro pro glu lys pro leu phe leu tyr leu ala leu gln ser 240
GTG CAT GAG CCC CTT CAG GTC CCT GAG GAA TAC TTG AAG CCA TAT
val his glu pro leu gln val pro glu glu tyr leu lys pro tyr 255
GAC TTT ATC CAA GAC AAG AAC AGG CAT CAC TAT GCA GGA ATG GTG
asp phe ile gln asp lys asn arg his his tyr ala gly met val 270
TCC CTT ATG GAT GAA GCA GTA GGA AAT GTC ACT GCA GCT TTA AAA
ser leu met asp glu ala val gly asn val thr ala ala leu lys 285
AGC AGT GGG CTC TGG AAC AAC ACG GTG TTC ATC TTT TCT ACA GAT
ser ser gly leu trp asn asn thr val phe ile phe ser thr asp 300
AAC GGA GGG CAG ACT TTG GCA GGG GGT AAT AAC TGG CCC CTT CGA
asn gly gly gln thr leu ala gly gly asn asn trp pro leu arg 315
GGA AGA AAA TGG AGC CTG TGG GAA GGA GGC GTC CGA GGG GTG GGC
gly arg lys trp ser leu trp glu gly gly val arg gly val gly 330
TTT GTG GCA AGC CCC TTG CTG AAG CAG AAG GGC GTG AAG AAC CGG
phe val ala ser pro leu leu lys gln lys gly val lys asn arg 345
GAG CTC ATC CAC ATC TCT GAC TGG CTG CCA ACA CTC GTG AAG CTG
glu leu ile his ile ser asp trp leu pro thr leu val lys leu 360
GCC AGG GGA CAC ACC AAT GGC ACA AAG CCT CTG GAT GGC TTC GAC
ala arg gly his thr asn gly thr lys pro leu asp gly phe asp 375
ATG TGG AAA ACC ATC AGT GAA GGA AGC CCA TCC CCC AGA ATT GAG
met trp lys thr ile ser glu gly ser pro ser pro arg ile glu 390
CTG CTG CAT AAT ATT GAC CCG AAC TTC GTG GAC TCT TCA CCG TGT
leu leu his asn ile asp pro asn phe val asp ser ser pro cys 405
CCC AGG AAC AGC ATG GCT CCA GCA AAG GAT GAC TCT TCT CTT CCA
pro arg asn ser met ala pro ala lys asp asp ser ser leu pro 420
GAA TAT TCA GCC TTT AAC ACA TCT GTC CAT GCT GCA ATT AGA CAT
glu tyr ser ala phe asn thr ser val his ala ala ile arg his 435
GGA AAT TGG AAA CTC CTC ACG GGC TAC CCA GGC TGT GGT TAC TGG
gly asn trp lys leu leu thr gly tyr pro gly cys gly tyr trp 450
TTC CCT CCA CCG TCT CAA TAC AAT GTT TCT GAG ATA CCC TCA TCA
phe pro pro pro ser gln tyr asn val ser glu ile pro ser ser 465
GAC CCA CCA ACC AAG ACC CTC TGG CTC TTT GAT ATT GAT CGG GAC
asp pro pro thr lys thr leu trp leu phe asp ile asp arg asp 480
CCT GAA GAA AGA CAT GAC CTG TCC AGA GAA TAT CCT CAC ATC GTC
pro glu glu arg his asp leu ser arg glu tyr pro his ile val 495
ACA AAG CTC CTG TCC CGC CTA CAG TTC TAC CAT AAA CAC TCA GTC
thr lys leu leu ser arg leu gln phe tyr his lys his ser val 510
CCC GTG TAC TTC CCT GCA CAG GAC CCC CGC TGT GAT CCC AAG GCC
pro val tyr phe pro ala gln asp pro arg cys asp pro lys ala 525
ACT GGG GTG TGG GGC CCT TGG ATG TAG
thr gly val trp gly pro trp met ter
Смотрите также:
