Рис. Col V AI seq
Нуклеотидная и аминокислотная последовательности
гена коллагена V типа альфа I (COL V AI) человека
ATG GAC GTC CAT ACC CGC TGG AAA GCG CGC AGC GCG CTC CGC CCG
met asp val his thr arg trp lys ala arg ser ala leu arg pro 15
GGC GCC CCG CTG CTG CCC CCG CTG CTG CTG CTG CTG CTG TGG GCG
gly ala pro leu leu pro pro leu leu leu leu leu leu trp ala 30
CCG CCT CCG AGC CGC GCA GCT CAG CCA GCA GAT CTC CTG AAG GTT
pro pro pro ser arg ala ala gln pro ala asp leu leu lys val 45
CTA GAT TTT CAC AAC TTG CCT GAT GGA ATA ACA AAG ACA ACA GGC
leu asp phe his asn leu pro asp gly ile thr lys thr thr gly 60
TTT TGC GCC ACG CGG CGA TCT TCC AAA GGC CCG GAT GTC GCT TAC
phe cys ala thr arg arg ser ser lys gly pro asp val ala tyr 75
AGA GTC ACC AAA GAC GCG CAG CTC AGC GCA CCC ACC AAG CAG CTG
arg val thr lys asp ala gln leu ser ala pro thr lys gln leu 90
TAC CCT GCG TCT GCA TTT CCC GAG GAC TTC TCC ATC CTA ACA ACT
tyr pro ala ser ala phe pro glu asp phe ser ile leu thr thr 105
GTG AAA GCC AAG AAA GGC AGC CAG GCC TTC CTG GTC TCC ATC TAC
val lys ala lys lys gly ser gln ala phe leu val ser ile tyr 120
AAC GAG CAG GGT ATC CAG CAG ATT GGG CTG GAG CTG GGC CGC TCT
asn glu gln gly ile gln gln ile gly leu glu leu gly arg ser 135
CCC GTC TTC CTC TAC GAG GAC CAC ACG GGG AAG CCT GGC CCG GAA
pro val phe leu tyr glu asp his thr gly lys pro gly pro glu 150
GAC TAC CCC CTC TTC CGG GGC ATC AAC CTG TCA GAT GGC AAG TGG
asp tyr pro leu phe arg gly ile asn leu ser asp gly lys trp 165
CAC AGA ATT GCT CTC AGC GTC CAC AAG AAA AAT GTC ACC TTG ATC
his arg ile ala leu ser val his lys lys asn val thr leu ile 180
CTC GAC TGT AAA AAG AAG ACC ACC AAA TTC CTC GAC CGC AGC GAC
leu asp cys lys lys lys thr thr lys phe leu asp arg ser asp 195
CAC CCC ATG ATC GAC ATC AAT GGC ATC ATC GTG TTT GGC ACC CGG
his pro met ile asp ile asn gly ile ile val phe gly thr arg 210
ATC CTG GAT GAG GAG GTG TTT GAG GGT GAC ATC CAG CAG CTG CTC
ile leu asp glu glu val phe glu gly asp ile gln gln leu leu 225
TTT GTC TCG GAC CAC CGG GCA GCT TAT GAT TAC TGT GAG CAC TAC
phe val ser asp his arg ala ala tyr asp tyr cys glu his tyr 240
AGC CCT GAC TGT GAC ACC GCA GTA CCT GAC ACC CCA CAG TCG CAG
ser pro asp cys asp thr ala val pro asp thr pro gln ser gln 255
GAC CCC AAT CCA GAT GAA TAT TAC ACG GAA GGA GAC GGC GAG GGT
asp pro asn pro asp glu tyr tyr thr glu gly asp gly glu gly 270
GAG ACC TAT TAC TAC GAA TAC CCC TAC TAC GAA GAC CCC GAA GAC
glu thr tyr tyr tyr glu tyr pro tyr tyr glu asp pro glu asp 285
CTA GGG AAG GAG CCC ACC CCC AGC AAG AAG CCC GTG GAA GCT GCC
leu gly lys glu pro thr pro ser lys lys pro val glu ala ala 300
AAA GAA ACC ACA GAG GTC CCC GAG GAG CTG ACC CCG ACC CCC ACG
lys glu thr thr glu val pro glu glu leu thr pro thr pro thr 315
GAA GCT GCT CCC ATG CCT GAA ACC AGT GAA GGG GCT GGG AAG GAA
glu ala ala pro met pro glu thr ser glu gly ala gly lys glu 330
GAG GAC GTC GGC ATC GGG GAC TAT GAC TAC GTG CCC AGT GAG GAC
glu asp val gly ile gly asp tyr asp tyr val pro ser glu asp 345
TAC TAC ACG CCC TCA CCG TAT GAT GAC CTC ACC TAT GGC GAG GGG
tyr tyr thr pro ser pro tyr asp asp leu thr tyr gly glu gly 360
GAG GAG AAC CCT GAC CAG CCC ACA GAC CCA GGC GCT GGG GCC GAA
glu glu asn pro asp gln pro thr asp pro gly ala gly ala glu 375
ATT CCC ACC AGC ACC GCC GAC ACC TCC AAC TCC TCC AAT CCA GCT
ile pro thr ser thr ala asp thr ser asn ser ser asn pro ala 390
CCG CCT CCA GGG GAA GGT GCG GAT GAC TTG GAG GGG GAG TTC ACT
pro pro pro gly glu gly ala asp asp leu glu gly glu phe thr 405
GAG GAA ACG ATC CGG AAC CTT GAC GAG AAC TAC TAC GAC CCC TAC
glu glu thr ile arg asn leu asp glu asn tyr tyr asp pro tyr 420
TAC GAC CCC ACC AGC TCC CCG TCG GAG ATC GGG CCG GGA ATG CCG
tyr asp pro thr ser ser pro ser glu ile gly pro gly met pro 435
GCG AAC CAG GAT ACC ATC TAT GAA GGG ATT GGA GGA CCT CGG GGC
ala asn gln asp thr ile tyr glu gly ile gly gly pro arg gly 450
GAG AAA GGC CAA AAG GGA GAA CCA GCG ATT ATC GAG CCG GGC ATG
glu lys gly gln lys gly glu pro ala ile ile glu pro gly met 465
CTC ATC GAG GGC CCG CCT GGC CCA GAA GGC CCC GCG GGT CTT CCC
leu ile glu gly pro pro gly pro glu gly pro ala gly leu pro 480
GGA CCT CCA GGA ACC ATG GGT CCC ACT GGC CAA GTC GGG GAC CCT
gly pro pro gly thr met gly pro thr gly gln val gly asp pro 495
GGA GAA AGG GGC CCC CCT GGA CGC CCA GGC CTT CCT GGG GCC GAT
gly glu arg gly pro pro gly arg pro gly leu pro gly ala asp 510
GGC CTG CCC GGT CCT CCA GGA ACC ATG CTC ATG CTG CCC TTC CGG
gly leu pro gly pro pro gly thr met leu met leu pro phe arg 525
TTT GGA GGT GGC GGC GAT GCG GGC TCC AAA GGC CCC ATG GTC TCA
phe gly gly gly gly asp ala gly ser lys gly pro met val ser 540
GCC CAG GAG TCC CAG GCG CAA GCC ATT CTC CAG CAG GCC AGG TTG
ala gln glu ser gln ala gln ala ile leu gln gln ala arg leu 555
GCA CTG AGG GGA CCA GCT GGC CCG ATG GGT CTC ACA GGG AGA CCT
ala leu arg gly pro ala gly pro met gly leu thr gly arg pro 570
GGC CCT GTG GGT CCC CCT GGG AGC GGA GGT TTG AAG GGC GAG CCG
gly pro val gly pro pro gly ser gly gly leu lys gly glu pro 585
GGA GAC GTG GGG CCT CAG GGT CCT CGA GGT GTG CAA GGC CCG CCT
gly asp val gly pro gln gly pro arg gly val gln gly pro pro 600
GGT CCG GCC GGG AAG CCC GGA AGA CGG GGT CGG GCT GGG AGT GAT
gly pro ala gly lys pro gly arg arg gly arg ala gly ser asp 615
GGA GCC AGA GGA ATG CCT GGA CAA ACT GGC CCC AAG GGT GAC CGG
gly ala arg gly met pro gly gln thr gly pro lys gly asp arg 630
GGT TTC GAC GGC CTG GCT GGG TTG CCA GGC GAG AAG GGC CAC AGG
gly phe asp gly leu ala gly leu pro gly glu lys gly his arg 645
GGT GAC CCT GGT CCT TCC GGC CCA CCA GGA CCT CCG GGA GAC GAT
gly asp pro gly pro ser gly pro pro gly pro pro gly asp asp 660
GGA GAA AGG GGT GAC GAC GGA GAA GTT GGG CCC AGG GGG CTG CCT
gly glu arg gly asp asp gly glu val gly pro arg gly leu pro 675
GGG AAG CCC GGG CCA CGT GGT CTG CTT GGG CCG AAA GGG CCC CCA
gly lys pro gly pro arg gly leu leu gly pro lys gly pro pro 690
GGT CCT CCC GGA CCT CCC GGT GTC ACG GGT ATG GAC GGC CAG CCG
gly pro pro gly pro pro gly val thr gly met asp gly gln pro 705
GGG CCA AAA GGA AAT GTG GGT CCC CAG GGA GAG CCT GGC CCC CCA
gly pro lys gly asn val gly pro gln gly glu pro gly pro pro 720
GGA CAG CAG GGT AAT CCA GGC GCC CAG GGT CTT CCA GGC CCC CAG
gly gln gln gly asn pro gly ala gln gly leu pro gly pro gln 735
GGT GCA ATT GGT CCT CCA GGA GAA AAG GGT CCC TTG GGG AAA CCA
gly ala ile gly pro pro gly glu lys gly pro leu gly lys pro 750
GGC CTT CCA GGA ATG CCC GGT GCT GAC GGA CCC CCG GGA CAC CCT
gly leu pro gly met pro gly ala asp gly pro pro gly his pro 765
GGC AAA GAA GGC CCT CCA GGA GAG AAA GGA GGT CAG GGT CCA CCT
gly lys glu gly pro pro gly glu lys gly gly gln gly pro pro 780
GGC CCC CAG GGT CCG ATT GGC TAC CCA GGT CCT CGA GGA GTC AAG
gly pro gln gly pro ile gly tyr pro gly pro arg gly val lys 795
GGG GCC GAT GGC ATC CGT GGT CTG AAG GGC ACA AAG GGC GAG AAG
gly ala asp gly ile arg gly leu lys gly thr lys gly glu lys 810
GGT GAA GAC GGC TTT CCT GGG TTT AAA GGA GAC ATG GGC ATC AAG
gly glu asp gly phe pro gly phe lys gly asp met gly ile lys 825
GGT GAT CGG GGG GAG ATC GGC CCA CCC GGT CCC AGG GGA GAA GAT
gly asp arg gly glu ile gly pro pro gly pro arg gly glu asp 840
GGC CCT GAA GGC CCA AAG GGT CGC GGA GGT CCC AAT GGT GAC CCC
gly pro glu gly pro lys gly arg gly gly pro asn gly asp pro 855
GGT CCT CTG GGA CCC CCT GGG GAG AAG GGA AAA CTC GGA GTC CCA
gly pro leu gly pro pro gly glu lys gly lys leu gly val pro 870
GGG TTA CCA GGG TAT CCA GGA AGA CAA GGA CCA AAG GGC TCT ATT
gly leu pro gly tyr pro gly arg gln gly pro lys gly ser ile 885
GGA TTC CCT GGA TTT CCT GGC GCC AAT GGA GAG AAG GGC GGC AGG
gly phe pro gly phe pro gly ala asn gly glu lys gly gly arg 900
GGG ACC CCT GGA AAG CCA GGA CCG CGG GGG CAG CGA GGC CCA ACG
gly thr pro ala lys pro gly pro arg gly gln arg gly pro thr 915
GGT CCG AGG GGT GAA AGA GGC CCC CGG GGC ATC ACT GGG AAG CCT
gly pro arg gly glu arg gly pro arg gly ile thr gly lys pro 930
GGC CCC AAG GGC AAC TCC GGA GGT GAC GGC CCA GCT GGC CCT CCT
gly pro lys gly asn ser gly gly asp gly pro ala gly pro pro 945
GGT GAA CGG GGA CCC AAT GGA CCC CAA GGA CCC ACA GGA TTT CCT
gly glu arg gly pro asn gly pro gln gly pro thr gly phe pro 960
GGA CCA AAG GGC CCC CCT GGC CCT CCA GGC AAG GAT GGA CTC CCA
gly pro lys gly pro pro gly pro pro gly lys asp gly leu pro 975
GGA CAC CCT GGA CAG AGA GGC GAG ACT GGT TTC CAA GGC AAG ACC
gly his pro gly gln arg gly glu thr gly phe gln gly lys thr 990
GGC CCT CCA GGC CCC CCC GGC GTG GTC GGC CCT CAG GGT CCC ACG
gly pro pro gly pro pro gly val val gly pro gln gly pro thr 1005
GGA GAA ACG GGC CCA ATG GGT GAG CGT GGC CAC CCT GGG CCC CCT
gly glu thr gly pro met gly glu arg gly his pro gly pro pro 1020
GGA CCC CCC GGT GAA CAG GGG CTT CCG GGC CTT GCT GGA AAA GAA
gly pro pro gly glu gln gly leu pro gly leu ala gly lys glu 1035
GGG ACG AAG GGT GAC CCA GGC CCT GCA GGC CTC CCT GGG AAA GAT
gly thr lys gly asp pro gly pro ala gly leu pro gly lys asp 1050
GGC CCT CCA GGA TTA CGT GGT TTC CCT GGG GAC CGA GGG CTT CCT
gly pro pro gly leu arg gly phe pro gly asp arg gly leu pro 1065
GGT CCA GTG GGA GCT CTT GGA CTG AAA GGC AAT GAA GGG CCC CCT
gly pro val gly ala leu gly leu lys gly asn glu gly pro pro 1080
GGC CCA CCA GGC CCT GCG GGA TCT CCA GGG GAG AGA GGT CCA GCT
gly pro pro gly pro ala gly ser pro gly glu arg gly pro ala 1095
GGA GCC GCT GGG CCC ATC GGA ATT CCA GGG AGA CCT GGG CCC CAG
gly ala ala gly pro ile gly ile pro gly arg pro gly pro gln 1110
GGA CCC CCA GGG CCG GCA GGA GAG AAA GGG GCT CCT GGC GAG AAA
gly pro pro gly pro ala gly glu lys gly ala pro gly glu lys 1125
GGC CCA CAA GGC CCA GCT GGC CGA GAC GGT CTC CAG GGG CCT GTG
gly pro gln gly pro ala gly arg asp gly leu gln gly pro val 1140
GGG CTC CCG GGT CCA GCT GGC CCT GTG GGT CCC CCT GGA GAA GAC
gly leu pro gly pro ala gly pro val gly pro pro gly glu asp 1155
GGA GAT AAG GGA GAG ATC GGG GAG CCG GGG CAG AAA GGA AGC AAG
gly asp lys gly glu ile gly glu pro gly gln lys gly ser lys 1170
GGG GAC AAA GGA GAA CAG GGT CCT CCT GGG CCT ACA GGT CCT CAA
gly asp lys gly glu gln gly pro pro gly pro thr gly pro gln 1185
GGC CCC ATC GGA CAG CCA GGC CCC TCT GGA GCT GAC GGC GAG CCG
gly pro ile gly gln pro gly pro ser gly ala asp gly glu pro 1200
GGG CCT CGG GGC CAG CAG GGC CTT TTC GGG CAG AAA GGT GAT GAA
gly pro arg gly gln gln gly leu phe gly gln lys gly asp glu 1215
GGT CCC AGA GGC TTT CCT GGA CCC CCT GGG CCA GTG GGG CTG CAG
gly pro arg gly phe pro gly pro pro gly pro val gly leu gln 1230
GGT TTG CCA GGA CCT CCA GGC GAG AAG GGT GAG ACA GGA GAC GTG
gly trp pro gly pro pro gly glu lys gly glu thr gly asp val 1245
GGC CAG ATG GGC CCC CCG GGT CCC CCT GGC CCC CGA GGA CCC TCC
gly gln met gly pro pro gly pro pro gly pro arg gly pro ser 1260
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