Рис. CBS seq
Нуклеотидная и аминокислотная последовательности
гена цистатионин бета-синтазы (CBS) человека
ATG CCT TCT GAG ACC CCC CAG GCA GAA GTG GGG CCC ACA GGC TGC
met pro ser glu thr pro gln ala glu val gly pro thr gly cys 15
CCC CAC CGC TCA GGG CCA CAC TCG GCG AAG GGG AGC CTG GAG AAG
pro his arg ser gly pro his ser ala lys gly ser leu glu lys 30
GGG TCC CCA GAG GAT AAG GAA GCC AAG GAG CCC CTG TGG ATC CGG
gly ser pro glu asp lys glu ala lys glu pro leu trp ile arg 45
CCC GAT GCT CCG AGC AGG TGC ACC TGG CAG CTG GGC CGG CCT GCC
pro asp ala pro ser arg cys thr trp gln leu gly arg pro ala 60
TCC GAG TCC CCA CAT CAC CAC ACT GCC CCG GCA AAA TCT CCA AAA
ser glu ser pro his his his thr ala pro ala lys ser pro lys 75
ATC TTG CCA GAT ATT CTG AAG AAA ATC GGG GAC ACC CCT ATG GTC
ile leu pro asp ile leu lys lys ile gly asp thr pro met val 90
AGA ATC AAC AAG ATT GGG AAG AAG TTC GGC CTG AAG TGT GAG CTC
arg ile asn lys ile gly lys lys phe gly leu lys cys glu leu 105
TTG GCC AAG TGT GAG TTC TTC AAC GCG GGC GGG AGC GTG AAG GAC
leu ala lys cys glu phe phe asn ala gly gly ser val lys asp 120
CGC ATC AGC CTG CGG ATG ATT GAG GAT GCT GAG CGC GAC GGG ACG
arg ile ser leu arg met ile glu asp ala glu arg asp gly thr 135
CTG AAG CCC GGG GAC ACG ATT ATC GAG CCG ACA TCC GGG AAC ACC
leu lys pro gly asp thr ile ile glu pro thr ser gly asn thr 150
GGG ATC GGG CTG GCC CTG GCT GCG GCA GTG AGG GGC TAT CGC TGC
gly ile gly leu ala leu ala ala ala val arg gly tyr arg cys 165
ATC ATC GTG ATG CCA GAG AAG ATG AGC TCC GAG AAG GTG GAC GTG
ile ile val met pro glu lys met ser ser glu lys val asp val 180
CTG CGG GCA CTG GGG GCT GAG ATT GTG AGG ACG CCC ACC AAT GCC
leu arg ala leu gly ala glu ile val arg thr pro thr asn ala 195
AGG TTC GAC TCC CCG GAG TCA CAC GTG GGG GTG GCC TGG CGG CTG
arg phe asp ser pro glu ser his val gly val ala trp arg leu 210
AAG AAC GAA ATC CCC AAT TCT CAC ATC CTA GAC CAG TAC CGC AAC
lys asn glu ile pro asn ser his ile ser asp gln tyr arg asn 225
GCC AGC AAC CCC CTG GCT CAC TAC GAC ACC ACC GCT GAT GAG ATC
ala ser asn pro leu ala his tyr asp thr thr ala asp glu ile 240
CTG CAG CAG TGT GAT GGG AAG CTG GAC ATG CTG GTG GCT TCA GTG
leu gln gln cys asp gly lys leu asp met leu val ala ser val 255
GGC ACG GGC GGC ACC ATC ACG GGC ATT GCC AGG AAG CTG AAG GAG
gly thr gly gly thr ile thr gly ile ala arg lys leu lys glu 270
AAG TGT CCT GGA TGC AGG ATC ATT GGG GTG GAT CCC GAA GGG TCC
lys cys pro gly cys arg ile ile gly val asp pro glu gly ser 285
ATC CTC GCA GAG CCG GAG GAG CTG AAC CAG ACG GAG CAG ACA ACC
ile leu ala glu pro glu glu leu asn gln thr glu gln thr thr 300
TAC GAG GTG GAA GGG ATC GGC TAC GAC TTC ATC CCC ACG GTG CTG
tyr glu val glu gly ile gly tyr asp phe ile pro thr val leu 315
GAC AGG ACG GTG GTG GAC AAG TGG TTC AAG AGC AAC GAT GAG GAG
asp arg thr val val asp lys trp phe lys ser asn asp glu glu 330
GCG TTC ACC TTT GCC CGC ATG CTG ATC GCG CAA GAG GGG CTG CTG
ala phe thr phe ala arg met leu ile ala gln glu gly leu leu 345
TGC GGT GGC AGT GCT GGC AGC ACG GTG GCG GTG GCC GTG AAG GCT
cys gly gly ser ala gly ser thr val ala val ala val lys ala 360
GCG CAG GAG CTG CAG GAG GGC CAG CGC TGC GTG GTC ATT CTG CCC
ala gln glu leu gln glu gly gln arg cys val val ile leu pro 375
GAC TCA GTG CGG AAC TAC ATG ACC AAG TTC CTG AGC GAC AGG TGG
asp ser val arg asn tyr met thr lys phe leu ser asp arg trp 390
ATG CTG CAG AAG GGC TTT CTG AAG GAG GAG GAC CTC ACG GAG AAG
met leu gln lys gly phe leu lys glu glu asp leu thr glu lys 405
AAG CCC TGG TGG TGG CAC CTC CGT GTT CAG GAG CTG GGC CTG TCA
lys pro trp trp trp his leu arg val gln glu leu gly leu ser 420
GCC CCG CTG ACC GTG CTC CCG ACC ATC ACC TGT GGG CAC ACC ATC
ala pro leu thr val leu pro thr ile thr cys gly his thr ile 435
GAG ATC CTC CGG GAG AAG GGC TTC GAC CAG GCG CCC GTG GTG GAT
glu ile leu arg glu lys gly phe asp gln ala pro val val asp 450
GAG GCG GGG GTA ATC CTG GGA ATG GTG ACG CTT GGG AAC ATG CTC
glu ala gly val ile leu gly met val thr leu gly asn met leu 465
TCG TCC CTG CTT GCC GGG AAG GTG CAG CCG TCA GAC CAA GTT GGC
ser ser leu leu ala gly lys val gln pro ser asp gln val gly 480
AAA GTC ATC TAC AAG CAG TTC AAA CAG ATC CGC CTC ACG GAC ACG
lys val ile tyr lys gln phe lys gln ile arg leu thr asp thr 495
CTG GGC AGG CTC TCG CAC ATC CTG GAG ATG GAC CAC TTC GCC CTG
leu gly arg leu ser his ile leu glu met asp his phe ala leu 510
GTG GTG CAC GAG CAG ATC CAG TAC CAC AGC ACC GGG AAG TCC AGT
val val his glu gln ile gln tyr his ser thr gly lys ser ser 525
CAG CGG CAG ATG GTG TTC GGG GTG GTC ACC GCC ATT GAC TTG CTG
gln arg gln met val phe gly val val thr ala ile asp leu leu 540
AAC TTC GTG GCC GCC CAG GAG CGG GAC CAG AAG TGA
asn phe val ala ala gln glu arg asp gln lys ter
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