Gene: [00.0/ARHGAP1] Rho GTPase activating protein 1 (p50); CDC42 GTPase activating protein 1; [p50rhoGAP ]
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FUN |
The ARHGAP1/CDC42GAP protein inactivates CDC42 (GEM:01p361/CDC42) by stimulating GTP hydrolysis. The CDC42GAP contains a functional SH3-binding domain (Barfod-1993). The Rho family members Rho (GEM:03q2/RHO), RAC (see GEM:00.0/RAC1), and CDC42 are suggested to be substrates for RHOGAP, with CDC42 the preferred substrate (Lancaster-1994)." |
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FAG |
The following genes coding for Rho GTPase activating proteins have been found: GEM 07p153/CHN2(ARHGAP3); GEM:0Xq28/ARHGAP4; GEM:00.0/ARHGAP5; GEM:0Xp223/ARHGAP6." |
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REF |
CLO,COD,EXP "Barfod ET &: JBC, 268, 26059-26062, 1993 CLO,SEQ,PEP "Barrett T &: Nature, 385, 458-461, 1997 PEP,SEQ "Garrett MD &: Biochem J, 276, 833-836, 1991 CLO,SEQ "Lancaster CA &: JBC, 269, 1137-1142, 1994 CLO,SEQ,PEP "Rittinger K &: Nature, 388, 693-697, 1997 |
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KEY |
sign |
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CLA |
coding, basic |
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LOC |
RS |
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MIM |
MIM: 602732 |
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SYN |
p50rhoGAP |
