Gene: [00.0/PRKMK7] protein kinase, mitogen-activated, kinase 7; MAP kinase kinase 7 (MAPKK 7); JNK-activating kinase 2;
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FUN |
[1] The JNKK2/PRKMK7 gene product is a specific activator of kinases JNK1
(GEM:10^/PRKM8) and JNK2 (GEM:05q35/PRKM9) participating thus in
modulating of gene expression (Wu-1997). About protein kinase
cascades see in: GEM:15q22/PRKMK1.
[2] The most potent activator of PRKM kinase 7 is MEKK1 (GEM:05^/MEKK1). Other activators are: MEKK2, GCK (GEM:11q13/RAB8IP), ASK1 (GEM:06q2233/MEKK5), RAC (e.g., GEM:00.0/RAC1), CDC42 (GEM:01p361/CDC42) (Wu-1997; Lu-1997; Foltz-1998), and constitutively active mutants of RAS (e.g., GEM:05q13/RASA1) (Foltz-1998)." |
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MOP |
The mRNA for MKK7 is widely expressed in humans and mice and encodes a 47-kDa protein (419 amino acids). The kinase domain of MKK7 is closely related to a Drosophila JNK kinase dHep (69% identity) and to a newly identified ortholog from C.elegans (54% identity), and was more distantly related to MKK3 (GEM:17q112/PRKMK3), MKK4 (GEM:17p112/SERK1), and MKK6 (GEM:00.0/PRKMK5) (Foltz-1998)." |
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REF |
COD,EXP,FUN "Foltz IN &: JBC, 273, 9344-9351, 1998 CLO,SEQ "Lu X &: JBC, 272, N40, 24751-24754, 1997 CLO,SEQ "Wu Z &: Mol Cell Biol, 17, N12, 7407-7416, 1997 |
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KEY |
pep, sign |
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CLA |
coding, basic |
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LOC |
RS |
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MIM |
MIM: 603014 |
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EZN |
ENZYME: 2.7.1.? |
