Gene: [15q22/PRKMK1] protein kinase, mitogen-activated, kinase 1 (43.5kD); MAP kinase kinase 1 (MAPKK 1);


FUN

[1] The general function of mitogen-activated protein kinase (MAPK) cascades is to relay environmental signals to the transcriptional machinery in the nucleus and thus modulate gene expression. MAPK cascades consist of a 3-kinase module composed of an MAPK (or PRKM, e.g. GEM:22q112/PRKM1), an MAPK kinase (MAPKK, or PRKMK), and an MAPKK kinase (MAPKKK, or MEKK, e.g. GEM:05^/MEKK1). Specific PRKMKs have been shown to phosphorylate specific PRKMs in a given module.
[2] At least 3 distinct MAPK cascades exist in mammals: one leads to the activation of the extracellular signal-regulated kinases (ERKs; e.g., GEM:16p112/PRKM3); another leads to the activation of the p38s (e.g., GEM:00.0/PRKM11); and a third leads to the activation of the c-jun N-terminal kinases (JNKs; see on them in GEM:10^/PRKM8)."

FAG

The other PRKMK genes have been found: GEM:00.0/PRKMK2; GEM:17q112/PRKMK3; GEM:17p112/SERK1(PRKMK4); GEM:00.0/PRKMK5; GEM:00.0/PRKMK6; GEM:00.0/PRKMK7."

REF

LOC "Rampoldi L &: CCG, 78, N3-4, 301-303, 1997
REV,FUN "Seger R, Krebs EG: FASEB J, 9, N9, 726-735, 1995
CLO,SEQ "Seger R &: JBC, 267, 25628-25631, 1992
CLO,SEQ "Zheng CF, Guan K &: JBC, 268, 11435-11439, 1993

SWI

SWISSPROT: Q02750

KEY

pep, sign

CLA

coding, basic

LOC

15 q22.1-.33

MIM

MIM: 176872

EZN

ENZYME: 2.7.1.?

鸯铗痂蝈 蜞赕:

  • HUGEN-觇磬玎 MAP 徨腙钼