Gene: [01p133/GSTM1] glutathione S-transferase M1 (mu class; H-b; liver); lung cancer? (susceptibility, in smoker);
FUN | [1]
Glutathione S-transferase participates in metabolism of various endogenous
and exogenous hydrophobic substances. It has a wide specificity. [2] Systematic name: RX:glutathione R-transferase. The catalyzed reaction: RX + glutathione = HX + R-S-G." |
FAG | According to preliminary data (Islam-1989), a GST1-like gene is located in Chr 3 (GEM:03^/GSTM1L). However, it can not be ruled out that this is one of the unmapped functional genes coding for other glutathione transferase isoforms. For more details on the localization of GST genes and classification of their products, see FAM:GST/00.0." |
HIS | Originally, the GSTM1/GST1 gene was thought to be located in Chr 11. However, Laisney-1983 and Suzuki-1984 demonstrated that it is actually GST3 (GEM:11q13/GSTP1) that is located there. GSTM1 has been mapped later to Chr 1p133." |
REL | GEM:03^/GSTM1L; GEM:01p133/GSTM2; GEM:01p133/GSTM3; GEM:01p133/GSTM4; GEM:01p133/GSTM5." |
REF | REV,FAG "Board PG &:
BBA, 953, 214-217, 1988 MEB,FOG,EXP,FAG "Board PG, Webb: PNAS, 84, N8, 2377-2381, 1987 MEB,FOG,EXP,FAG "Board PG: AJHG, 33, 36-43, 1981a REV "Board PG: AJHG, 33, 36-43, 1981b REV,FAG "Chow NW &: JBC, 263, N26, 12797-12800, 1988 PRO,CYG,MOL,POL "DeJong JL &: CCG, 51, (HGM10), 986, 1989 LOC,SEQ,EXP "DeJong JL &: NAR, 16, 8541-8554, 1988 MEB,FOG,EXP,FAG "Harada &: Hum Genet, 75, 322-325, 1987 LOC,CYG,MOL,EXP "Islam MQ &: Hum Genet, 82, 338-342, 1989 REV "Laisney V &: Hum Genet, 68, N3, 221-227, 1984 LOC,CYG "Laisney V &: Ann Genet, 26, 69-74, 1983 SEQ,EVO "Mannervik B &: PNAS, 82, N21, 7202-7206, 1985a REV "Mannervik B: Adv Enzymol Relat Areas Mol Biol, 57, 357-417, 1985b MEB,FOG,EXP,FAG "Scott, Wright: AJHG, 32, 115-117, 1980 PAT,PAT,NOM "Seidegard J &: Carcinogenesis, 11, N1, 33-36, 1990 SEQ,POL,MUT,POP "Seidegard J &: PNAS, 85, N19, 7293-7297, 1988 PAT,PAT,NOM "Seidegard J &: Carcinogenesis, 7, N5, 751-753, 1986 LOC,CYG "Silberstein DL &: CCG, 32, (HGM6), 317, 1982a LOC,CYG "Silberstein DL, Shows: Somat Cell Genet, 8, N5, 667-675, 1982b MEB,FOG,EXP,FAG "Strange &: Biochem Genet, 23, 1011-1028, 1985 MEB,FOG,EXP,FAG "Strange &: Ann Hum Genet, 48, 11-20, 1984 MEB,FOG,EXP,FAG "Suzuki &: Ann Hum Genet, 51, 95-106, 1987 LOC,CYG "Suzuki, Board: Somat Cell Mol Genet, 10, N3, 319-320, 1984 |
SWI | SWISSPROT: P09488 |
KEY | xen |
CLA | coding, basic |
LOC | 01 p13.3 |
MIM | MIM: 138350 |
EZN | ENZYME: 2.5.1.18 |
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