Gene: [01q21/MUC1] mucin 1, urinary (epithelial; peanut lectin binding); episialin (carcinoma-associated mucin 1); breast carcinoma-associated antigen DF3 (mucin 1; episialin); [BCAM DF3 EMA ]


COM

[1] Originally, the peptide product was identified using monoclonal antibodies against different protein epitopes in many laboratories. For this reason, this mucin type is often named by the names of respective antibodies, HMFG-1, HMFG-2, Ca1, DF3, anti-EMA, OM-1, SM-3, and SM-4 (Taylor-Papadimitriou-1981; Ashall-1982). An early review on this subject appeared in: Hilkens &, in: Monoclonal Antibodies and Breast Cancer, ed Ceriani RL, Martinus Nijhoff, Hague, Netherlands, pp 28-42, 1985.
[2] The abbreviation PUM for the gene symbol was introduced by V.A.McKusick and reflects the ability of the protein urine fraction to bind a peanut lectin: Peanut-reactive Urinary Mucin. However, the main fraction of this protein is found in different tumor cell lines of epithelial origin, and especially in metastatic breast cancer; so one of the common names is the breast cancer DF3 antigen (Siddiqui-1988). The name 'episialin' came from the laboratory of J.Hilkens (Ligtenberg-1990)."

MOP

Varying number of tandem repeats of a 20-amino-acid oligopeptide is characteristic for mucins. This results in the allelic polymorhism of the protein length. At the gene level, this is related with the pronounced restriction fragment length polymorphism (RFLP) which pattern corresponds to that of hypervariable loci (HVR) of minisatellite DNA."

FAG

Several other mucin genes are identified: GEM:11p155/MUC2; GEM:07q22/MUC3; GEM:03q29/MUC4; GEM:11p155/MUC5AC; GEM:11p155/MUC5B; GEM:11p155/MUC6; GEM:04q/MUC7; GEM:12q243/MUC8, and GEM:00.0/MUC18."

REF

LOC,LIN,MAG,MAP "Anderson &: CCG, 51, (HGM10), 950, 1989
IDN,PEP "Ashall &: Lancet, 2, 1-6, 1982
IDN,PEP "Burchell &: Cancer Res, 47, 5476-5482, 1987
IDN,PEP "Cordell &: Brit J Cancer, 52, 347-354, 1985
IDN,PEP "DeKretser &: Eur J Cancer Clin Oncol, 21, 1019-1035, 1985
PRO,EXP "Gendler SJ &: PNAS, 84, N17, 6060-6064, 1987
IDN,POL,PEP,FOG "Hayes &: Blood, 71, 436-440, 1988
IDN,PEP "Hilkens &: Int J Cancer, 34, 197-206, 1984
IDN,POL,PEP,FOG "Karlsson &: Ann Hum Genet, 47, 263-269, 1983
IDN,PEP "Kufe &: Hybridoma, 3, 223-232, 1984
SEQ,EXP,GEN,STR "Ligtenberg MJL &: JBC, 265, N10, 5573-5578, 1990
LOC,LIN,MAG,MAP "Middleton-Price &: Ann Hum Genet, 52, (Part 4), 273-278, 1988a
LOC,LIN,MAG,MAP "Middleton-Price &: Ann Hum Genet, 52, 273-278, 1988b
LOC,LIN,MAG,MAP "O'Connell P &: Genomics, 4, N1, 12-20, 1989
POL "Pratt WS &: Ann Hum Genet, 60, (Part 1), 21-28, 1996
PRO,EXP "Siddiqui J &: PNAS, 85, N7, 2320-2323, 1988
LOC,LIN,MAG,MAP "Swallow DM &: Ann Hum Genet, 52, (Part 4), 269-271, 1988
LOC,MOL,CYG,LIN "Swallow DM &: Ann Hum Genet, 51, 289-294, 1987a
LOC,MOL,CYG,LIN "Swallow DM &: CCG, 46, (HGM9), 701, 1987b
IDN,POL,PEP,FOG "Swallow DM &: Nature, 328, 82-84, 1987c
IDN,PEP "Taylor-Papadimitriou &: Int J Cancer, 28, 17-21, 1981

KEY

exce, mem, onc

CLA

coding, basic

LOC

01 q21

MIM

MIM: 158340

SYN

BCAM DF3 EMA

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