Gene: [01q21/PIK4CB] phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, type III (wortmannin-sensitive);


COM

The PIK4CB gene was mapped to 1q21 by somatic cell hybrid analysis, radiation hybrid analysis, and FISH (Saito-1997; Suzuki-1997)."

FUN

Phosphatidylinositol 4-kinases catalyze the synthesis of phosphatidylinositol-4-phosphate, the immediate precursor of phosphatidylinositol-4,5-diphosphate (Meyers-1997). The PIK4CB enzyme is inhibited by 150 nM wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides (Nakanishi-1995)."

REF

COD,SEQ,PEP "Meyers R, Cantley LC: JBC, 272, N7, 4384-4390, 1997
FUN,MEB,EXP "Nakanishi S &: PNAS, 92, 5317-5321, 1995
CLO,SEQ,LOC "Saito T &: DNA Res, 4, N4, 301-305, 1997
CLO,SEQ,LOC "Suzuki K &: DNA Res, 4, 273-280, 1997

KEY

lip, neu

CLA

coding, basic

LOC

01 q21

MIM

MIM: 602758

EZN

ENZYME: 2.7.1.67

Смотрите также:

  • Gene: [03q263/PIK3CA] phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;
  • Gene: [00.0/PIK4CA] phosphatidylinositol 4-kinase, catalytic, alpha (55kD);