Gene: [01q32/REN] renin (angiotensinogenase);


COM

Before 1981 EC:3.4.99.19 was accepted.

GEN

The gene lengthis 12 kb. Exons: 10; introns: 9.

FUN

[1] Renin cleaves the bond in angiotensinogen (GEM:01q4/AGT) producing angiotensin I.
[2] About the renin-angiotensin system, which includes this enzyme, see GEM:17q23/DCP1."

REL

GEM:0Xq28/RENBP.

REF

EXP,FUN,MOL "Bruneval &: Am J Pathol, 131, N2, 320-330, 1988
LIN,MAG "Buetow &: CCG, 51, (HGM10), 972, 1989
TRC,SEQ,EVO "Burt &: JBC, 264, N13, 7257-7362, 1989
POL,MOL "Chen, Easteal: Hum Genet, 82, 302, 1989
LOC,MOL,CYG "Chirgwin &: Somat Cell Mol Genet, 10, N4, 415-421, 1984
LOC,MOL,CYG "Cohen-Hagenauer &: CCG, 46, (HGM9), 597, 1987
POL,FOG "Frossard PM &: NAR, 14, 4380, 1986
GEN,SEQ,EVO "Fukamizu A &: Gene, 49, 139-145, 1986
LOC,MOL,CYG "Griffiths LR &: CCG, 45, 231-233, 1987
GEN,SEQ,EVO "Hardman JA &: DNA, 3, N6, 457-468, 1984
GEN,SEQ,EVO "Hobart PM &: PNAS, 81, (Aug), 5026-5030, 1984
SEQ,PEP,CAG,MOU "Imai T &: PNAS, 80, 7405-7409, 1983
LOC,PRO "McGill JR &: CCG, 45, 55-57, 1987
LOC,MOL,CYG "Middleton-Price &: CCG, 46, (HGM9), 662, 1987
GEN,SEQ,EVO "Miyazaki H &: PNAS, 81, N19, 5999-6003, 1984
POL,FOG "Morris BJ, Griffiths: BBRC, 150, N1, 219-224, 1988
GEN,MOP,EVO "Murakami, Ueno: Proc Jpn Acad Sci, 61, (B), N6, 257-260, 1985
LOC,PRO "Nakai H &: CCG, 47, N1-2, 90-91, 1988
LOC,MOL,CYG "Naylor &: CCG, 37, (HGM7), 549-550, 1984
SEQ,EXP "Soubrier F &: NAR, 11, 7181-7190, 1983

SWI

SWISSPROT: P00797

KEY

horm, pep

CLA

coding, basic

LOC

01 q32

MIM

MIM: 179820

EZN

ENZYME: 3.4.23.15

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