Gene: [01q4/AGT] angiotensinogen (angiotensin I; angiotensin II); predisposition to essential hypertension (predisposition to preeclampsia);


FAG

[1] Products of this gene are substrates for renin (GEM:01q32/REN) and dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme; GEM:17q23/DCP1). All these proteins are components of the renin-angiotensin system (see GEM:17q23/DCP1).
[2] The product of the protooncogene mas-1 is supposed (Jackson-1988) to be a cell receptor for angiotensin (see GEM:06q2/MAS1).
[3] About angiotensin receptors see, for example, GEM:03q2/AGTR1A.
[4] On angiotensin binding protein see GEM:00.0/AGTBP."

REF

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LOC "Isa MN &: Genomics, 8, N3, 598-600, 1990
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PRO,COD,EXP "Kunapuli SP, Kumar A: Circ Res, 60, 786-790, 1987b
MUT,ASS "Russ AP &: Hum Mol Genet, 2, 609-610, 1993
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SWI

SWISSPROT: P01019

KEY

horm, card, neu

CLA

coding, basic

LOC

01 q42-43

MIM

MIM: 106150

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