Gene: [01q4/AGT] angiotensinogen (angiotensin I; angiotensin II); predisposition to essential hypertension (predisposition to preeclampsia);
FAG | [1]
Products of this gene are substrates for renin (GEM:01q32/REN) and dipeptidyl carboxypeptidase 1
(angiotensin I converting enzyme; GEM:17q23/DCP1). All these proteins are components of
the renin-angiotensin system (see GEM:17q23/DCP1). [2] The product of the protooncogene mas-1 is supposed (Jackson-1988) to be a cell receptor for angiotensin (see GEM:06q2/MAS1). [3] About angiotensin receptors see, for example, GEM:03q2/AGTR1A. [4] On angiotensin binding protein see GEM:00.0/AGTBP." |
REF | MUT,ASS
"Arngrimsson R &: Nature Genet, 4, 114-115, 1993 POG "Bloem LJ &: J Clin Invest, 95, 948-953, 1995 LIN,PAT "Caulfield M &: J Clin Invest, 96, 687-692, 1995 LIN,PAT "Caulfield M &: New Engl J Med, 330, 1629-1633, 1994 MUT,ASS "Fornage M &: Hum Genet, 96, 295-300, 1995 CLO,GEN,SEQ "Fukamizu A &: JBC, 265, 7576-7582,1990 CLO,GEN,SEQ "Gaillard I &: DNA, 8, 87-99, 1989 MUT,ASS "Hata A &: J Clin Invest, 93, 1285-1287, 1994 LOC "Isa MN &: Genomics, 8, N3, 598-600, 1990 LOC,PRO "Isa MN &: AJHG, 45, A144, 1989 FAG,REL "Jackson TR &: Nature, 335, 437-440, 1988 MUT,ASS "Jeunemaitre X &: Cell, 71, 7-20, 1992 PRO,COD,EXP "Kageyama R &: Biochemistry, 23, 3603-3609, 1984 MUT,ASS "Katsuya T &: Lancet, 345, 1600-1603, 1995 PRO,COD,EXP "Kunapuli SP &: JBC, 262, 7672-7675, 1987a PRO,COD,EXP "Kunapuli SP, Kumar A: Circ Res, 60, 786-790, 1987b MUT,ASS "Russ AP &: Hum Mol Genet, 2, 609-610, 1993 PRO,GEN,STR,RAT,EVO "Tanaka T &: JBC, 259, N13, 8063-8065, 1984 MUT,ASS "Ward K &: Nature Genet, 4, 59-61, 1993 |
SWI | SWISSPROT: P01019 |
KEY | horm, card, neu |
CLA | coding, basic |
LOC | 01 q42-43 |
MIM | MIM: 106150 |
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