Gene: [01q32/TNNI1] troponin I1, skeletal, slow; [TNN1 ]


COM

Corin-1994 have cloned the gene encoding the human slow twitch skeletal muscle isoform of troponin I and have identified 5'-flanking sequences required for its expression in skeletal muscle cells (Corin-1994)."

GEN

The gene length: 12.5 kb; exons: 9 (Corin-1994).

EXP

The 'slow' isoform of troponin I is expressed during early heart and skeletal muscle development but is restricted to slow twitch skeletal muscle in the adult. In contrast to many muscle-specific genes, the troponin I promoter does not contain consensus CCAAT or TATA elements. Moreover, the sequence from -9 to +11 resembles an 'initiator element' previously shown to direct transcription of some tissue-specific genes lacking TATA boxes (Calvo-1996). A transcriptional fusion construct, comprising 4.2 kilobases of troponin I 5'-flanking DNA linked to the bacterial chloramphenicol acetyl-transferase gene, exhibited cell type-specific and developmentally regulated expression. A muscle-specific enhancer regulated slow troponin I promoter activity (Corin-1994)."

REF

TRC,GEN "Calvo &: Dev Genet, 19, N2, 169-181, 1996
GEN,SEQ,EXP "Corin SJ &: JBC, 269, 10651-10659, 1994
LOC "Eyre HJ &: CCG, 62, N2-3, 181-182, 1993
COD,SEQ,LOC,EXP "Wade R &: Genomics, 7, 346-357, 1990
GEN,EXP,EVO "Weis L, Reinberg D: FASEB J, 6, 3300-3309, 1992

SWI

SWISSPROT: P19237

KEY

myo

CLA

coding, basic

LOC

01 q32

MIM

MIM: 191042

SYN

TNN1

Смотрите также:

  • Gene: [03p/TNNC1] troponin C1, cardiac and skeletal, slow; [TNCC TNC ]
  • Gene superfamily: troponins I; (TNNI1 TNNI2 TNNI3)
  • Gene: [22q1/PVALB] parvalbumin;
  • HUGEN-тропонин
  • HUGEN-тропонин I