Gene: [03p/TNNC1] troponin C1, cardiac and skeletal, slow; [TNCC TNC ]
COM | Bermingham-1995 mapped a gene (symbolized by them as TNNC1) to Chr 19q13.3-.4. Song-1997 indicated that this gene represented cardiac troponin I (GEM:19^/TNNI3). By PCR analysis, Song-1996 assigned TNNC1 gene to Chr 3p21.3-p14.3. Townsend-1997 confirmed the location to short arm of Chr 3 by somatic cell hybrid analysis." |
FUN | The troponin C is a Ca(2+)-binding subunit of the troponin complex which serves as a calcium-sensitive switch for striated muscle contraction. See details in FAM:TNNC/00.0." |
PEP | The amino acid sequence of human skeletal muscle troponin-C is established by Romero-Herrera-1976 and the amino acid sequence of troponin-C (consisting of 161 residues) from human cardiac muscle is reported by Roher-1986. The cardiac and slow-twitch skeletal troponin C are presumably identical (Romero-Herrera-1976)." |
GEN | The gene length: 3 kb; exons: 6; introns: 5 (Schreier-1990). |
FAG | Troponin C1 belongs to the same multigene family as calmodulins, parvalbumin, and others do (see GEM:14q32/CALM1, GEM:22q1/PVALB)." |
REL | GEM:03p/TNNC1; GEM:20q1/TNNC2; GEM:01q32/TNNI1; GEM:11p155/TNNI2; GEM:19^/TNNI3; GEM:19q134/TNNT1; GEM:01q32/TNNT2; GEM:11p155/TNNT3." |
REF | COM,EAG "Bermingham N
&: Genomics, 30, 620-622, 1995 FUN,REL "Nadal-Ginard B, Mahdavi: J Clin Invest, 84, N6, 1693-1700, 1989 IDN,PEP,FUN,SEQ "Roher A &: Muscle Nerve, 9, 73-77, 1986 FUN,PEP,SEQ "Romero-Herrera AE &: J Mol Evol, 8, 251-270, 1976 COD,SEQ,EVO "Schreier T &: JBC, 265, 21247-21253, 1990 LOC "Song W-J &: CCG, 75, N1, 36-37, 1996 LOC,LIN "Townsend PJ &: Ann Hum Genet, 61 (Part 4), 375-377, 1997 |
SWI | SWISSPROT: P02590 |
KEY | myo, card |
CLA | coding, basic |
LOC | 03 p21.3-14.3 |
MIM | MIM: 191040 |
SYN | TNCC TNC |
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