Gene: [02p25/ODC1] ornithine decarboxylase 1;


FUN

The enzyme catalyzes the convertion of L-ornithine into putrescine. This is the first (limiting) stage of polyamine synthesis: L-ornithine = putrescine + CO(2)."

PRO

Probe pODC10/2H (a 2.0 kb cDNA fragment) has been cloned in pBR322 at EcoRI site. In Northern blotting, the probe for ODC identifies one major mRNA species (2.2 kb); in Southern blotting, the probe identifies only two genomic ODC sequences that are located in different chromosomes. Thus, ODC2 (or (pseudogene also symbolized ODCP) is located in Chr 7q3."

PSG

GEM:07q3/ODCP.

REF

EXP,EAG "Alhonen-Hongisto L &: Biochem J, 242, 205-210, 1987
COD,SEQ,EXP "Hickok NJ &: DNA, 6, 179-187, 1987
PRO,EXP "Holtta E &: Gene, 83, 125-135, 1989
FUN "Ohno &: BBA, 284, 285-?, 1972
FAG,LOC,PRO "Radford DM &: CCG, 46, (HGM9), 678, 1987
FAG,LOC,PRO "Winqvist R &: CCG, 42, 133-140, 1986
FAG,LOC,PRO "Yang-Feng TL &: Genomics, 1, N1, 77-86, 1987

SWI

SWISSPROT: P11926

KEY

mito, urea, aac

CLA

coding, basic

LOC

02 p25

MIM

MIM: 165640

EZN

ENZYME: 4.1.1.17

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