Gene: [02q3/SCYA20] small inducible cytokine subfamily A (Cys-Cys), member 20; beta-chemokine Exodus; macrophage inflammatory protein 3 alpha (MIP-3-alpha); liver and activation-regulated chemokine (LARC); [MIP3A LARC ]
COM | Hromas-1997 reported the cloning and characterization of a novel human chemokine that they termed 'Exodus' for its chemotactic properties. This novel chemokine is distantly related to other chemokines (e.g., 28% homology with MIP-1-alpha, see GEM:17q112/SCYA3) and shares several of their biologic activities." |
EVO | The sequence homology, expression, and biologic activity indicated that Exodus represents a novel, divergent beta-chemokine." |
EXP | Exodus is expressed preferentially in lymphocytes and monocytes, and its expression is markedly upregulated by mediators of inflammation such as tumor necrosis factor (see GEM:06p2133/TNFA) and lipopolysaccaride." |
FUN | Purified synthetic Exodus was found to inhibit proliferation of myeloid progenitors in colony formation assays. Exodus also stimulated chemotaxis of peripheral blood mononuclear cells." |
REF | CLO,SEQ,LOC
"Hieshima K &: JBC, 272, N9, 5846-5853, 1997 COD,SEQ,EXP,FUN "Hromas R &: Blood, 89, 3315-3322, 1997 IDN "Rossi DL &: J Immunol, 158, N3, 1033-1036, 1997 |
SWI | SWISSPROT: P78556 |
KEY | imm, cyk |
CLA | coding, basic |
LOC | 02 q33-37 |
MIM | MIM: 601960 |
SYN | MIP3A LARC |
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