Gene: [06p2133/-] tumor necrosis factor, alpha (cachectin A); cachectin A (macrophage-derived); Crohn disease (TNF-associated haplotype); [TNF ]



GEN

The gene length: 3 kb.

FAG

Two genes encoding for receptor peptides of tumor necrosis growth factor have been identified: GEM:12p13/TNFR1; GEM:01p362/TNFR2."

REL

GEM:06p2133/TNFB; GEM:06p2133/LTB; GEM:17q2/TNFAI1. See also GEM:00.0/TACE.

REF

FUN,PEP "Aggarwal &: JBC, 260, N4, 2334-2344, 1985a
FUN,PEP "Aggarwal &: Nature, 318, 665-667, 1985b
LOC,MAP,MAF "Carrol &: PNAS, 84, N23, 8535-8539, 1987
HIS,FUN "Carswell &: PNAS, 72, 3666-3671, 1975
PAT,MUT "Dulleman HM &: Gastroenterology, 109, 129-135, 1995
HIS,FUN "Helson L &: Nature, 258, N5537, 731-732, 1975
LOC,MAP,MAF "Inoko H, Trowsdale J: NAR, 15, 8957-8962, 1987
STR,MOP,MEB "Jones EY &: Nature, 338, (16 Mar), 225-228, 1989
LOC,MAP,MAF "Nedospasov SA &: Dokl Akad Nauk SSSR, 287, 1487-1490, 1986a
GEN,MAP,EVO "Nedospasov SA &: NAR, 14, 7713-7725, 1986b
FAG,GEN,LOC "Nedwin GE &: NAR, 13, N17, 6361-6373, 1985
REV,GEN,FUN "Oliff A: Cell, 54, (15 Jul), 141-142, 1988
PRO,SEQ,EXP "Pennica D &: Nature, 312, N5996, 724-729, 1984
PAT,MUT "Plevy SE &: Gastroenterology, 110, 1053-1060, 1996
LOC,MAP,MAF "Ragoussis J &: Immunogenetics, 27, 66-69, 1988
PRO,GEN,SEQ "Shirai T &: Nature, 313, (28 Feb), N6005, 803-806, 1985
LOC,MAP,MAF "Spies T &: PNAS, 83, N22, 8699-8702, 1986
PRO,SEQ,EXP "Wang AM &: Science, 228, 149-154, 1985

KEY

imm, onc

CLA

coding, basic

LOC

06 p21.33

MIM

MIM: 191160

SYN

TNF

:

  • Gene: [15q2/B2M] beta-2-microglobulin; hemodialysis-related amyloidosis (HRA); carpal tunnel syndrome (posthemodialysis);
  • Gene: [15q211/CYP19] cytochrome P450, subfamily XIX (aromatization of androgens); gynecomastia, familial (increased aromatase activity);
  • - ( -)
  • Gene: [02q3/SCYA20] small inducible cytokine subfamily A (Cys-Cys), member 20; beta-chemokine Exodus; macrophage inflammatory protein 3 alpha (MIP-3-alpha); liver and activation-regulated chemokine (LARC); [MIP3A LARC ]
  • Gene: [06p213/DIF2] differentiation-dependent gene 2; PACAP-responsive gene 1; immediate-early response gene IEX1; [GLY96 IEX1 PR ]
  • -
  • HUGEN-