Gene: [03q2/ATR] ataxia telangiectasia and Rad3 (S.pombe) related; FRAP-related protein 1; [FRP1 ]
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COM |
The Rad3 gene of S.pombe is required for checkpoint pathways that respond to DNA damage and replication blocks. Bentley-1996 showed that Rad3 is the homologue of S.cerevisiae Mec1p and D.melanogaster Mei-41 checkpoint genes. Authors identified a novel human gene (ATR) whose product is closely related to Rad3/Mec1p/Mei-41 and human FRAP gene (GEM:01p362/FRAP1) involved in a rapamycin-sensitive pathway leading to G1 cell cycle progression. Cimprich-1996 also cloned this gene and assigned it to Chr 3q22-24." |
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REF |
CLO,SEQ "Bentley NJ &: EMBO J, 15, N23, 6641-6651, 1996 CLO,LOC "Cimprich KA &: PNAS, 93, N7, 2850-2855, 1996 FUN "Smith L &: Nature Genet, 19, 39-46, 1998 |
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CLA |
coding, basic |
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LOC |
03 q22-24 |
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MIM |
MIM: 601215 |
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SYN |
FRP1 |
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