Gene: [04q12/PAICS] phosphoribosylaminoimidazole carboxylase (AIR carboxylase; EC:4.1.1.21); phosphoribosylaminoimidazole succinocarboxamide synthetase (SAICAR synthetase; EC:6.3.2.6);
|
FAG |
[1] Brayton-1994 found that PAICS (required for steps 6 (AIR carboxylase)
and 7 (SAICAR synthetase) of de novo synthesis of purine nucleotides)
and PPAT (catalyzes step 1; GEM:04q12/PPAT)
are closely linked and
divergently transcribed.
[2] GDB have registered another locus coding multifunctional SAICAR synthetase/AIR carboxylase: GEM:08p23/ADE2C1." |
|
REL |
GEM:00.0/PAICSP1; GEM:00.0/PAICSP2. |
|
REF |
CLO,LOC "Barton JW &: Genomics, 9, 314-321, 1991 EXP "Brayton KA &: JBC, 269, 5313-5321, 1994 LIN,LOC,EXP "Gavalas A &: Mol Cell Biol, 13, 4784-4792, 1993 LOC "Schild D &: PNAS, 87, 2916-2920, 1990 |
|
KEY |
nucm |
|
CLA |
coding, basic |
|
LOC |
04 q12 |
|
MIM |
MIM: 172439 |
|
EZN |
ENZYME: 4.1.1.21 |
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