Gene: [04q12/PPAT] phosphoribosyl pyrophosphate amidotransferase;
FAG | Brayton-1994 found that PPAT (catalyzes step 1 of de novo synthesis of purine nucleotides) and PAICS (required for steps 6 and 7; GEM:04q12/PAICS) are closely linked and divergently transcribed." |
FUN | The reaction catalyzed: 5-phospho-beta-D-ribosylamine + pyrophosphate + L-glutamate = = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O." |
PSG | GEM:00.0/PPATP1. |
REF | EXP "Brayton KA &: JBC, 269, 5313-5321, 1994 FUN "Chu &: PNAS, 68, 3459-3463, 1972 FUN "Feldman, Taylor: Biochem Genet, 13, 227-234, 1975 LIN,LOC,EXP "Gavalas A &: Mol Cell Biol, 13, 4784-4792, 1993 LOC "Jones &: CCG, 40, (HGM8), 662-663, 1985 LOC "Stanley W, Chu: CCG, 22, (HGM4), 228-231, 1978 |
SWI | SWISSPROT: Q06203 |
KEY | repr, nucm |
CLA | coding, basic |
LOC | 04 q12 |
MIM | MIM: 172450 |
EZN | ENZYME: 2.4.2.14 |
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