Gene: [04q21/GRO1] oncogene GRO1 (GRO-alpha; melanoma growth stimulating activity); neutrophil-activating protein 3; [GRO NAP3 MGSA ]
COM | The location 4q21 is indicated on the basis of data (Buetow-1989) on the complete linkage of GRO1 (MGSA) with the gene of gamma-interferon-inducible protein IP10, wich was previously mapped to q21 (GEM:04q21/IFNI10). Richmond-1988, studying the in situ hybridization of gene-specific probe on chromosomes, demonstrated that a significant peak of hybridization signal corresponds to subsegment q13, which is the nearest one to q21 (from the centromere side)." |
EVO | The melanoma growth factor is highly homologous to the protein IP10 and the group of peptides involved in the inflammatory responses (IRP, Inflammatory Response Peptides). The IRP group includes, in particular, platelet factor 4 (GEM:04q/PF4) and pro-platelet basic protein (PPBP), which is the precursor of the peptide CTAP III and beta-thromboglobulin (GEM:04q1/PPBP; see also Holt-1986)." |
FAG | GRO oncogenes (see also GEM:04q21/GRO2 and GEM:04q21/GRO3) belong to small inducible cytokines B - cytokine subfamily with C-X-C motif." |
REF | PRO,SEQ,EXP,EVO
"Anisowicz A &: PNAS, 85, N24, 9645-9649, 1988 PRO,SEQ,EXP,EVO "Anisowicz A &: PNAS, 84, N20, 7188-7192, 1987 PRO,SEQ,EXP,EVO "Baker NE &: NAR, 18, 6453, 1990 PRO,SEQ,EXP,EVO "Buetow KH &: AJHG, 48, 911-925, 1991 MAG,LOC,POL "Buetow KH &: CCG, 51, (HGM10), 973, 1989 PRO,SEQ,EXP,EVO "Fairbrother WJ &: J Mol Biol, 242, 252-270, 1994 PRO,SEQ,EXP,EVO "Fairbrother WJ &: FEBS Lett, 330, 302-306, 1993 PRO,SEQ,EXP,EVO "Goold RD &: Hum Mol Genet, 2, 1271-1288, 1993 PRO,SEQ,EXP,EVO "Haskill S &: PNAS, 87, 7732-7736, 1990 FAG,EAG,EVO "Holt JC &: Biochemistry, 25, 1988-1996, 1986 IDN,FUN "Richmond A, Thomas: J Cell Biochem, 36, 185-198, 1988a PRO,SEQ,EXP,FUN,EVO,LOC "Richmond A &: EMBO J, 7, N7, 2025-2033, 1988b IDN,FUN "Richmond A &: J Invest Derm, 86, 295-302, 1986 IDN,FUN "Richmond A &: Cancer Res, 45, 6390-6394, 1985 IDN,FUN "Richmond A &: Cancer Res, 42, 3175-3180, 1982 MAG,LOC,POL "Sakaguchi AY &: CCG, 51, (HGM10), 1072, 1989 |
SWI | SWISSPROT: P09341 |
KEY | onc, derm, cyk |
CLA | coding, basic |
LOC | 04 q21 |
MIM | MIM: 155730 |
SYN | GRO NAP3 MGSA |
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