Gene: [04q/PF4] platelet factor 4;
MOP | The protein contains 70 amino acid residues. |
TIS | Factor PF4 is secreted from the alpha granules of activated platelets." |
FUN | Factor PF4 binds heparin, locally inhibits antithrombin III, and neutralizes heparin-like substances on the surface of vascular endothelium." |
EVO | Factor PF4 shares homology with other platelet-secreted proteins: beta-thromboglobulin (GEM:04q1/PPBP), interferon-inducible cytokine IP10 (GEM:04q21/IFNI10), and melanoma growth stimulating factor (GEM:04q21/GRO1)." |
PRO | Probe pF4 contains a 1.4-kb gDNA fragment cloned in M13MP18 phage and covering two-thirds of the 3'-region of PF4 gene." |
REL | GEM:04q/PF4V1. |
REF | LOC,MOL,PRO "Griffin
CA &: CCG, 45, 67-69, 1987 POL,MOL "Guzzo C &: NAR, 15, 380, 1987 CLO,SEQ,EXP,EVO "Poncz M &: Blood, 69, 219-223, 1987 |
SWI | SWISSPROT: P02776 |
KEY | hem, clot |
CLA | coding, basic |
LOC | 04 q12-21 |
MIM | MIM: 173460 |
