Gene: [04q2/PPP3CA] protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; calcineurin A alpha;
FUN | [1]
Calcineurin A is a calcium-dependent, calmodulin-stimulated protein
phosphatase (serine/threonine-specific). [2] Catalytic activity: phosphoprotein + H(2)O = protein + orthophosphate." |
MOP | Calcineurin is composed of the calmodulin-binding catalytic subunit (calcineurin A; 61 kD; derived from at least 3 structural genes, see GEM:10q2/PPP3CB; GEM:08^/PPP3CC) and calcium-binding subunit (calcineurin B; 19kD; GEM:02p1/PPP3R1; GEM:00.0/PPP3R2)." |
REL | GEM:11q13/PPP1CA |
REF | LOC "Giri PR &: BBRC,
181, 252-258, 1991 SEQ,PEP,MOP,EXP "Guerini D, Klee: PNAS, 86, 9183-9187, 1989 LOC,FAG "Wang MG &: CCG, 72, N2-3, 236-241, 1996 |
SWI | SWISSPROT: Q08209 |
KEY | pep |
CLA | coding, basic |
LOC | 04 q21-24 |
MIM | MIM: 114105 |
EZN | ENZYME: 3.1.3.16 |
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