Gene: [04q2/PPP3CA] protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; calcineurin A alpha;


FUN

[1] Calcineurin A is a calcium-dependent, calmodulin-stimulated protein phosphatase (serine/threonine-specific).
[2] Catalytic activity: phosphoprotein + H(2)O = protein + orthophosphate."

MOP

Calcineurin is composed of the calmodulin-binding catalytic subunit (calcineurin A; 61 kD; derived from at least 3 structural genes, see GEM:10q2/PPP3CB; GEM:08^/PPP3CC) and calcium-binding subunit (calcineurin B; 19kD; GEM:02p1/PPP3R1; GEM:00.0/PPP3R2)."

REL

GEM:11q13/PPP1CA

REF

LOC "Giri PR &: BBRC, 181, 252-258, 1991
SEQ,PEP,MOP,EXP "Guerini D, Klee: PNAS, 86, 9183-9187, 1989
LOC,FAG "Wang MG &: CCG, 72, N2-3, 236-241, 1996

SWI

SWISSPROT: Q08209

KEY

pep

CLA

coding, basic

LOC

04 q21-24

MIM

MIM: 114105

EZN

ENZYME: 3.1.3.16

Смотрите также:

  • HUGEN-фосфатазы серин-треониновые
  • HUGEN-2В фосфатаза
  • HUGEN-фосфатаза PP3
  • HUGEN-PP3 фосфатаза
  • HUGEN-фосфатаза 2B