Gene: [04q31/IL15] interleukin 15;
FUN | Interleukin 15 exhibits many of the same biological properties as IL2 (GEM:04q2/IL2), including the activation and proliferation of T cells and specific interaction with the beta and gamma subunits of the IL2 receptor (GEM:22q13/IL2RB; GEM:0Xq131/IL2RG; Giri-1994; Grabstein-1994). The distribution of IL15 mRNA and IL15-receptor-alpha mRNA (GEM:10p1/IL15RA) suggests that IL-15 may have biological activities distinct from IL-2 (Giri-1995) and a broader range of cellular targets (Anderson-1995a)." |
REL | See GEM:02q13/IL1A. |
REF | FAG,EXP "Anderson DM
&: JBC, 270, 29862-29869, 1995a PRO,LOC,EAG,HUM,MOU "Anderson DM &: Genomics, 25, 701-706, 1995b CLO,EXP,FUN,FAG "Giri JG &: EMBO J, 14, 3654-3663, 1995 MOP,FUN,EXP "Giri JG &: EMBO J, 13, 2822-2830, 1994 COD,FUN,EXP,TIS "Grabstein KH &: Science, 264, N5161, 965-968, 1994 |
SWI | SWISSPROT: P40933 |
KEY | imm, cyk, onc |
CLA | coding, basic |
LOC | 04 q31 |
MIM | MIM: 600554 |
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