Gene: [05q311/IRF1] interferon regulatory factor 1 (activator);


COM

The GDB assigned IRF1 gene less precisely: 5q23-31 [GDB:G00-127-269:Loc='05 q23-31'].

FUN

The IRF1 gene product binds virus-inducible cis-elements of alpha- and beta-interferon genes (Miyamoto-1988; FAM:IFN9/09p22), thus activating interferon transcription (Harada-1989) and participating in interferon-mediated regulation of cell growth (as suggested by Fujita-1989)."

REL

GEM:04q351/IRF2; GEM:00.0/IRF3; GEM:06p2/IRF4; GEM:07q32/IRF5; GEM:00.0/IRF6; GEM:00.0/IRF7."

REF

EXP,FUN "Fujita &: Nature, 337, 270-272, 1989a
EXP,FUN "Fujita &: PNAS, 86, 9936-9940, 1989b
LOC,FAG "Harada H &: Mol Cell Biol, 14, 1500-1509, 1994
EXP,FUN "Harada H &: Cell, 63, 303-312, 1990
EXP,FUN "Harada H &: Cell, 58, 729-739, 1989
PAT,MUT,POL "Itoh K &: J Clin Invest, 87, 177-186, 1991
LOC,POL "Itoh S &: Genomics, 10, 1097-1099, 1991
MUT,LOC "Le Beau MM &: PNAS, 90, 5484-5488, 1993
PRO,SEQ "Maruyama M &: NAR, 17, 3292, 1989
EXP,FUN,MEB "Miyamoto M &: Cell, 54, 903-913, 1988
MUT,LOC "Willman CL &: Science, 259, 968-971, 1993
MOU,MOD,ENG "Yamada G &: PNAS, 88, 532-536, 1991

SWI

SWISSPROT: P10914

KEY

cyk, trc

CLA

coding, basic

LOC

05 q31.1

MIM

MIM: 147575

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