Gene: [05q31/IL4] interleukin 4 (B cell stimulatory factor-1); [BCGF1 BSF1 ]
COM | GDB indicates the IL4 location less precisely: 05q23-31 [GDB:G00-120-096:LOC='05 q23-31']. However, IL4 was mapped to 5q31 by many investigators (Sutherland-1988; Saltman-1993). By fluorescence in situ hybridization, Le Beau et al. mapped the gene to 5q31.1 (Le Beau-1993)." |
LIN | The IL4 and IL5 genes (GEM:05q31/IL5) are tightly linked (Chandrasekharappa-1990). |
GEN | The gene length: 10 kb. Exons: 4. Introns: 3 (0.272, 5.2, and 2.588 kb). Propeptide has been deduced to contain 153 amino acid residues, the mature peptide, 120 amino acid residues." |
PRO | The probe is an expressible vector pcD-HIL-4
(clone 46); it contains a 0.6 kb cDNA fragment (with |
FAG | Two proteins have been described as constituents of the IL-4 receptor, a approximately 140-kDa glycoprotein (GEM:16p121/IL4R) and the gamma chain of the IL-2 receptor (GEM:0Xq131/IL2RG)." |
REL | See GEM:02q13/IL1A. |
REF | GEN,SEQ,EVO,LOC "Arai
N &: J Immunol, 142, N1, 274-282, 1989 MAF,LIN,MOL,FAG "Chandrasekharappa &: Genomics, 6, N1, 94-99, 1990 GEN,MOP,EXP "Eder A &: NAR, 16, N2, 772, 1988 LOC,PRO,FAG "Le Beau MM &: PNAS, 90, 5484-5488, 1993 LOC,PRO,FAG "Le Beau MM &: Blood, 73, N3, 647-650, 1989 LOC,LIN "Saltman DL &: Genomics, 16, 726-732, 1993 MOP,REL "Smirnov DV &: Gene, 155, 277-281, 1995 LOC,PRO,FAG "Sutherland GR &: Hum Genet, 79, 335-337, 1988 LOC,EVO,MOU,FAG "Takahashi M &: Genomics, 4, 47-52, 1989 GEN,FAG,MAF "van Leeuwen BH &: Blood, 73, N5, 1142-1148, 1989 PRO,SEQ,EXP "Yokota T &: PNAS, 83, N16, 5894-5898, 1986 |
SWI | SWISSPROT: P05112 |
KEY | imm, cyk, onc |
CLA | coding, basic |
LOC | 05 q31 |
MIM | MIM: 147780 |
SYN | BCGF1 BSF1 |
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