Gene: [06q253/IGF2R] insulin-like growth factor 2 receptor; somatomedin A receptor (IGF2 receptor); mannose 6-phosphate receptor, cation-independent; [MPRI MPRCI ]
FUN | The cation-independent (M6PRI) form of MAN-6-P receptor binds lysosomal hydrolases that penetrate into cell by endocytosis. See also GEM:12p13/M6PRD." |
EVO | Sequencing of the gene
revealed that the cation-independent receptor, M6PRI, is almost identical
to the IGF2R receptor for insulin-like cytokin II (99.4% by the amino acid sequence and 99.8% by the nucleotide one)." |
FAG | The gene for the cation-dependent form (GEM:12p13/M6PRD) have been mapped and sequenced. This form provides binding of intracellular lysosomal hydrolases." |
REF | FUN,PEP,EXP "Brown &: J Cell Biol, 103, 1235-1247, 1986 REV,FUN,STR "Eriksson, Lonnroth: J Int Med, 225, 43-45, 1989 FUN,PEP,EXP "Gartung &: EMBO J, 4, 1725-1730, 1985 FUN,PEP,EXP "Graham &: PNAS, 83, N12, 4519-4523, 1986 FUN,PEP,EXP "Hoflack, Kornfeld: JBC, 262, 123-129, 1987 FUN,PEP,EXP "Hoflack, Kornfeld: JBC, 260, 12008-12014, 1985a FUN,PEP,EXP "Hoflack, Kornfeld: PNAS, 82, 4428-4432, 1985b FUN,MEB,MOP "Kiess W &: JBC, 263, 9339-9443, 1988 FUN,PEP,EXP "Kornfeld S: J Clin Invest, 77, 1-6, 1986 LOC,EVO "Laureys G &: Genomics, 3, 224-229, 1988 PRO,SEQ,MOP "Morgan DO &: Nature, 329, 301-307, 1987 FUN,PEP,EXP "Nishimoto I &: JBC, 262, N25, 12120-12126, 1987 FUN,PEP,EXP "Nolan &: J Cell Biochem, 35, 137-151, 1987 PRO,SEQ,MOP "Oshima A &: JBC, 263, N5, 2553-2562, 1988 REV,FUN,STR "Roth RA: Science, 239, (11 Mar), 1269-1271, 1988 FUN,PEP,EXP "Roth RA &: BBRC, 149, N2, 600-606, 1987 FUN,PEP,EXP "Stein &: EMBO J, 6, 2677-2681, 1987 FUN,MEB,MOP "Waheed A &: BBRC, 152, 1248-1254, 1988 |
SWI | SWISSPROT: P11717 |
KEY | recp, lys, horm |
CLA | coding, basic |
LOC | 06 q25.3 |
MIM | MIM: 147280 |
SYN | MPRI MPRCI |
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