Gene: [12p13/M6PRD] mannose 6-phosphate receptor, cation-dependent; [M6PR MAN6PRD]
FUN | Two types of mannose 6-phosphate receptor are known. One of them (cation-dependent, encoding by M6PRD gene) binds lysosomal hydrolases that are synthesized inside the cell, and the other (cation-independent, encoding by M6PRI gene) binds hydrolases that enter the cell via endocytosis." |
FAG | M6PRI gene is mapped and sequenced (see GEM:06q253/IGF2R). |
EVO | See GEM:06q253/IGF2R. |
REF | FUN,PEP "Brown &: J
Cell Biol, 103, 1235-1247, 1986 PRO,SEQ,EXP "Dahms &: Cell, 50, 181-192, 1987 FUN,PEP "Gartung &: EMBO J, 4, 1725-1730, 1985 FUN,PEP "Hoflack, Kornfeld: JBC, 262, 123-129, 1987 FUN,PEP "Hoflack, Kornfeld: JBC, 260, 12008-12014, 1985a FUN,PEP "Hoflack, Kornfeld: PNAS, 82, 4428-4432, 1985b FUN,PEP "Kornfeld S: J Clin Invest, 77, 1-6, 1986 FUN,PEP "Nolan &: J Cell Biochem, 35, 137-151, 1987 FUN,MOP "Oshima A &: JBC, 263, N5, 2553-2562, 1988 PRO,SEQ,MOP,LOC "Pohlmann R &: PNAS, 84, N16, 5575-5579, 1987 FUN,PEP "Stein &: EMBO J, 6, 2677-2681, 1987 |
SWI | SWISSPROT: P20645 |
KEY | recp, lys, mtbd, carb |
CLA | coding, basic |
LOC | 12 p13 |
MIM | MIM: 154540 |
SYN | M6PR MAN6PRD |
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