Gene: [06q27/APOLPA] apolipoprotein Lp(a) (pre-beta-1 system); atherosclerosis, liability to; lower plasma apo(a) concentration, association with;
FUN | Lp(a) glycoprotein, in conjunction with apolipoprotein B (GEM:02p2/APOB), forms the lipoprotein(a) serum system. The system is an important factor of atherogenesis and pathogenesis of coronary disease. Apo(a) is thought to have proteolytic activity resembling that of plasmin (EC:3.4.21.7)." |
MOP | [1] Usually a
lipoprotein(a) particle contains two apo(a) molecules which are covalently
bound to the apoB100 molecule by the disulfide bridges. [2] Recently an interindividual polymorphism of number of repeats within 'kringle IV' region of Lp(a) peptide have been found (Kondo-1990). This polymorphism might explain the presence of Lp(a) isoforms described in Uterman-1987,1988a,1988b." |
FOG | Increased serum Lp(a) is inherited as quasi-dominant mendelian trait. |
ASS | Increased serum Lp(a) is thought to be an important risk factors for coronary disease that is independent of other factors, such as nutrition, smoking and, hormonal status." |
EVO | The amino acid sequence of this protein shows the high homology to that of plasminogen, which gene (GEM:06q2/PLG) is also located in Chr 6q and closely linked with the APOLPA." |
BIB | The bibliography on the general problems of atherogenesis, coronary disease and the role of other apolipoprotein serum systems is available in FAM:APOLP/00.0." |
LIK | GEM:06q27/APOLPAL1, GEM:06q27/APOLPAL2. |
REF | LOC,LIN "Berg K &:
CCG, 51, (HGM10), 961, 1989 PHE,FOG "Berg K &: Clin Genet, 16, 347-352, 1979 HIS "Berg K: Vox Sang, 12, 71-74, 1967 HIS "Berg K, Mohr: Acta Genet Statist Med, 13, 349-360, 1963 PHE,FOG "Breckenridge, Maguire: Clin Biochem, 14, 82-86, 1981 PEP,SEQ,EVO "Eaton &: PNAS, 84, N10, 3224-3228, 1987 FUN,PEP "Fless &: JBC, 259, N18, 11470-11478, 1984 LOC,LIN "Frank SL &: Hum Genet, 79, 352-356, 1988 FUN,MEB "Hajjar &: Nature, 339, N6222, 303-305, 1989 PHE,FOG "Hasstedt &: Am J Med Genet, 16, 179-188, 1983 PHE,FOG "Hewitt &: Clin Genet, 21, 301-308, 1982 POL,ASS "Ichinose A, Kuriyama M: BBRC, 209, N1, 372-378, 1995 PHE,FOG "Iselius &: Clin Genet, 20, 147-151, 1981 PRO,POL,MOL,MUT "Kondo, Berg: Clin Genet, 37, 132-140, 1990 PHE,FOG "Koshechkin &: Genetika, 17, N11, 2025-2033, 1981 LOC,LIN "Lindahl G &: Hum Genet, 81, 149-152, 1989 REV,FUN,MEB,STR,PAT "Mbewu, Durrington: Atherosclerosis, 85, N1, 1-15, 1990 PRO,SEQ,EVO "McLean JW &: Nature, 330, 132-137, 1987 FUN,MEB "Miles &: Nature, 339, N6222, 301-303, 1989 PHE,FOG "Utermann G &: Hum Genet, 78, 41-46, 1988a PHE,FOG "Utermann G &: Hum Genet, 78, 47-50, 1988b PHE,FOG "Utermann G &: J Clin Invest, 80, 458-465, 1987 POL,ASS "Wade DP &: PNAS, 90, N4, 1369-1373, 1993 LOC,LIN "Weitkamp LR &: Hum Genet, 79, 80-82, 1988 |
SWI | SWISSPROT: P08519 |
KEY | ats, card, lip |
CLA | coding, basic |
LOC | 06 q27 |
MIM | MIM: 152200 |
EZN | ENZYME: 3.4.21.? |
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